Christophe Pignier
Overview
Explore the profile of Christophe Pignier including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
162
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Recent Articles
1.
Morelot-Panzini C, Perez T, Sedkaoui K, de Bock E, Aguilaniu B, Devillier P, et al.
Respir Med
. 2018 Dec;
145:1-7.
PMID: 30509697
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder leading to chronic respiratory failure. Few studies have investigated ALS-related dyspnoea, and none have characterised the emotional distress it inflicts. We...
2.
Morelot-Panzini C, Gilet H, Aguilaniu B, Devillier P, Didier A, Perez T, et al.
Eur Respir J
. 2016 Apr;
47(6):1668-79.
PMID: 27076585
Dyspnoea is a prominent symptom of chronic obstructive pulmonary disease (COPD). Recent multidimensional dyspnoea questionnaires like the Multidimensional Dyspnea Profile (MDP) individualise the sensory and affective dimensions of dyspnoea. We...
3.
Perez M, Lamothe M, Maraval C, Mirabel E, Loubat C, Planty B, et al.
J Med Chem
. 2009 Oct;
52(19):5826-36.
PMID: 19791800
Protease activated receptors (PARs) or thrombin receptors constitute a class of G-protein-coupled receptors (GPCRs) implicated in the activation of many physiological mechanisms. Thus, thrombin activates many cell types such as...
4.
Le Grand B, Pignier C, Letienne R, Colpaert F, Cuisiat F, Rolland F, et al.
J Med Chem
. 2009 Jun;
52(14):4149-60.
PMID: 19514733
We report the discovery of a selective, potent inhibitor of the late current mediated by the cardiac isoform of the sodium channel (Na(V)1.5). The compound, 3,4-dihydro-N-[(2S)-3-[(2-hydroxy-3-methylphenyl)thio]-2-methylpropyl]-2H-(3R)-1,5-benzoxathiepin-3-amine (2d) (F 15741), blocks...
5.
6.
Le Grand B, Pignier C, Letienne R, Cuisiat F, Rolland F, Mas A, et al.
J Med Chem
. 2008 Jun;
51(13):3856-66.
PMID: 18529044
We describe the discovery of the first selective, potent, and voltage-dependent inhibitor of the late current mediated by the cardiac sodium channel Na V1.5. The compound 3,4-dihydro- N-[(2 S)-3-[(2-methoxyphenyl)thio]-2-methylpropyl]-2 H-(3...
7.
Pinet C, Algalarrondo V, Sablayrolles S, Le Grand B, Pignier C, Cussac D, et al.
Mol Pharmacol
. 2008 Mar;
73(6):1622-31.
PMID: 18326052
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds...
8.
Keller M, Pignier C, Egger M, Niggli E
Cardiovasc Drug Rev
. 2007 Oct;
25(3):210-20.
PMID: 17919256
F90927 is a newly developed cardioactive drug with a steroid-like structure. It acts directly and agonistically on the cardiac L-type Ca2+ channel by shifting its voltage-dependent activation toward more negative...
9.
Pignier C, Revenaz C, Rauly-Lestienne I, Cussac D, Delhon A, Gardette J, et al.
Basic Res Cardiol
. 2007 Sep;
102(6):553-64.
PMID: 17891522
Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic and eicosapentaenoic acids (DHA, EPA) exert ischemic anti-arrhythmic effects. However, their mechanism of action remains unknown. The present study was designed to investigate...
10.
Keller M, Pignier C, Santelli M, Vacher B, Niggli E, Egger M
Cell Calcium
. 2006 Mar;
39(5):425-33.
PMID: 16540165
In cardiac muscle the amplitude of Ca(2+) transients can be increased by enhancing Ca(2+) influx. Among the processes leading to increased Ca(2+) influx, agonists of the L-type Ca(2+)-channel can play...