Klaus Rajewsky
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Explore the profile of Klaus Rajewsky including associated specialties, affiliations and a list of published articles.
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197
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17301
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Recent Articles
1.
Li X, Chu V, Kocks C, Rajewsky K
Bio Protoc
. 2024 Nov;
14(20):e5085.
PMID: 39512884
The adoptive transfer of autologous, long-lived, gene-repaired T cells is a promising way to treat inherited T-cell immunodeficiencies. However, adoptive T-cell therapies require a large number of T cells to...
2.
Tran N, Graf R, Acevedo-Ochoa E, Trombke J, Weber T, Sommermann T, et al.
Leukemia
. 2024 Jul;
38(9):2003-2015.
PMID: 39043964
Hematopoiesis is a continuous process of blood cell production driven by hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Proliferation and differentiation of HSPCs are regulated by complex...
3.
Iwakoshi N, Lee A, Vallabhajosyula P, Otipoby K, Rajewsky K, Glimcher L
Nat Immunol
. 2024 Apr;
25(5):928.
PMID: 38600358
No abstract available.
4.
Li X, Wirtz T, Weber T, Lebedin M, Lowenstein E, Sommermann T, et al.
Sci Immunol
. 2024 Feb;
9(92):eadi0042.
PMID: 38306418
Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently needed....
5.
Zhang J, Sommermann T, Li X, Gieselmann L, de la Rosa K, Stecklum M, et al.
Front Immunol
. 2024 Jan;
14:1331730.
PMID: 38169736
Introduction: Epstein-Barr virus (EBV) infection in humans is associated with a wide range of diseases including malignancies of different origins, most prominently B cells. Several EBV latent genes are thought...
6.
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, et al.
Nat Commun
. 2023 Nov;
14(1):6947.
PMID: 37935654
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements...
7.
Griger J, Widholz S, Jesinghaus M, de Andrade Kratzig N, Lange S, Engleitner T, et al.
Cancer Cell
. 2023 Jun;
41(7):1327-1344.e10.
PMID: 37352862
Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome sequencing to characterize the genomic landscapes of human G-NEC...
8.
Tran N, Lebedin M, Danner E, Kuhn R, Rajewsky K, Chu V
Bio Protoc
. 2023 Apr;
13(8):e4661.
PMID: 37113334
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains...
9.
Winkler W, Farre Diaz C, Blanc E, Napieczynska H, Langner P, Werner M, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(10):e2219439120.
PMID: 36853944
Multiple myeloma (MM), a tumor of germinal center (GC)-experienced plasma cells, comprises distinct genetic subgroups, such as the t(11;14)/CCND1 and the t(4;14)/MMSET subtype. We have generated genetically defined, subgroup-specific MM...
10.
Xiong E, Popp O, Salomon C, Mertins P, Kocks C, Rajewsky K, et al.
Front Immunol
. 2023 Jan;
13:1083119.
PMID: 36685499
Introduction: The differentiation of B cells into antibody-secreting plasma cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood. Methods: We have developed a CRISPR/Cas9-based screen...