Marc-Jan Gubbels
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Explore the profile of Marc-Jan Gubbels including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Elsworth B, Ye S, Dass S, Tennessen J, Sultana Q, Thommen B, et al.
Science
. 2025 Feb;
387(6734):eadq6241.
PMID: 39913579
Measures to combat the parasites that cause malaria have become compromised because of reliance on a small arsenal of drugs and emerging drug resistance. We conducted a transposon mutagenesis screen...
2.
Tagoe D, Ribeiro E Silva A, Drozda A, Coppens I, Coleman B, Gubbels M
Sci Rep
. 2024 Sep;
14(1):21819.
PMID: 39294204
Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations differentiated by dependence on Rab5A/C in their biogenesis. Calcium-dependent...
3.
Lou J, Rezvani Y, Arriojas A, Wu Y, Shankar N, Degras D, et al.
Nat Commun
. 2024 Aug;
15(1):7419.
PMID: 39198388
Sequential lytic cycles driven by cascading transcriptional waves underlie pathogenesis in the apicomplexan parasite Toxoplasma gondii. This parasite's unique division by internal budding, short cell cycle, and jumbled up classically...
4.
Engelberg K, Bauwens C, Ferguson D, Gubbels M
bioRxiv
. 2024 Jun;
PMID: 38826480
One of the defining features of apicomplexan parasites is their cytoskeleton composed of alveolar vesicles, known as the inner membrane complex (IMC) undergirded by intermediate-like filament network and an array...
5.
Zarringhalam K, Ye S, Lou J, Rezvani Y, Gubbels M
Curr Opin Microbiol
. 2023 Oct;
76:102383.
PMID: 37898053
The cell division cycle of T. gondii is driven by cyclically expressed ApiAP2 transcription factors (AP2s) that promote gene sets (regulons) associated with specific biological functions. AP2s drive other AP2s,...
6.
Elsworth B, Keroack C, Rezvani Y, Paul A, Barazorda K, Tennessen J, et al.
Res Sq
. 2023 Mar;
PMID: 36909484
Apicomplexan egress from host cells is fundamental to the spread of infection and is poorly characterized in spp., parasites of veterinary importance and emerging zoonoses. Through the use of video...
7.
Duraisingh M, Gubbels M, Zarringhalam K
PLoS Biol
. 2023 Jan;
21(1):e3001997.
PMID: 36696650
Twenty years ago, the first transcriptome of the intraerythrocytic developmental cycle of the malaria parasite Plasmodium falciparum was published in PLOS Biology. Since then, transcriptomics studies have transformed the study...
8.
Rezvani Y, Keroack C, Elsworth B, Arriojas A, Gubbels M, Duraisingh M, et al.
PLoS Biol
. 2022 Sep;
20(9):e3001816.
PMID: 36137068
Babesia is a genus of apicomplexan parasites that infect red blood cells in vertebrate hosts. Pathology occurs during rapid replication cycles in the asexual blood stage of infection. Current knowledge...
9.
Engelberg K, Bechtel T, Michaud C, Weerapana E, Gubbels M
Nat Commun
. 2022 Aug;
13(1):4644.
PMID: 35941170
The basal complex (BC) is essential for T. gondii cell division but mechanistic details are lacking. Here we report a reciprocal proximity based biotinylation approach to map the BC's proteome....
10.
Nasuhidehnavi A, Zhao Y, Punetha A, Hemphill A, Li H, Bechtel T, et al.
Infect Immun
. 2022 Aug;
90(8):e0020522.
PMID: 35913173
The role of specific host cell surface receptors during Toxoplasma gondii invasion of host cells is poorly defined. Here, we interrogated the role of the well-known malarial invasion receptor, basigin,...