Isabelle Coppens
Overview
Explore the profile of Isabelle Coppens including associated specialties, affiliations and a list of published articles.
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149
Citations
10581
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Recent Articles
1.
Alves E Silva T, Kanatani S, Barletta Ferreira A, Schwartz C, Talyuli O, Olivas J, et al.
bioRxiv
. 2025 Mar;
PMID: 40060675
sporozoites, the stage that initiates a malaria infection, must invade the mosquito salivary glands (SGs) before transmitting to a vertebrate host. However, the effects of sporozoite invasion on salivary gland...
2.
Tagoe D, Ribeiro E Silva A, Drozda A, Coppens I, Coleman B, Gubbels M
Sci Rep
. 2024 Sep;
14(1):21819.
PMID: 39294204
Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations differentiated by dependence on Rab5A/C in their biogenesis. Calcium-dependent...
3.
Li Z, Asady B, Chang L, Triana M, Li C, Coppens I, et al.
bioRxiv
. 2024 Aug;
PMID: 39185237
Ca signaling in cells begins with the opening of Ca channels in either the plasma membrane (PM) or the endoplasmic reticulum (ER) and results in a dramatic increase in the...
4.
Giuliano C, Wei K, Harling F, Waldman B, Farringer M, Boydston E, et al.
Nat Microbiol
. 2024 Jul;
9(9):2323-2343.
PMID: 38977907
Examining host-pathogen interactions in animals can capture aspects of infection that are obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire genome of the apicomplexan parasite Toxoplasma...
5.
Quan J, Nikolov L, Sha J, Wohlschlegel J, Coppens I, Bradley P
PLoS Biol
. 2024 May;
22(5):e3002634.
PMID: 38713739
Toxoplasma gondii resides in its intracellular niche by employing a series of specialized secretory organelles that play roles in invasion, host cell manipulation, and parasite replication. Rab GTPases are major...
6.
Antunes A, Shahinas M, Swale C, Farhat D, Ramakrishnan C, Bruley C, et al.
Nature
. 2023 Dec;
625(7994):366-376.
PMID: 38093015
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental...
7.
Bhalchandra S, Gevers K, Heimburg-Molinaro J, van Roosmalen M, Coppens I, Cummings R, et al.
Infect Immun
. 2023 Sep;
91(10):e0027523.
PMID: 37725059
species are a leading cause of pediatric diarrheal disease and death in low- and middle-income countries and pose a particular threat to immunocompromised individuals. As a zoonotic pathogen, can have...
8.
Asady B, Sampels V, Romano J, Levitskaya J, Lige B, Khare P, et al.
PLoS Pathog
. 2023 Aug;
19(8):e1011566.
PMID: 37651449
As an obligate intracellular parasite, Toxoplasma gondii must import essential nutrients from the host cell into the parasitophorous vacuole. We previously reported that the parasite scavenges cholesterol from host endocytic...
9.
Huang W, Rodrigues J, Bilgo E, Tormo J, Challenger J, De Cozar-Gallardo C, et al.
Science
. 2023 Aug;
381(6657):533-540.
PMID: 37535741
Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non-genetically modified symbiotic bacterium, TC1, which was isolated from mosquitoes...
10.
Ferrel A, Romano J, Panas M, Coppens I, Boothroyd J
mSphere
. 2023 Jun;
8(4):e0067022.
PMID: 37341482
is an obligate, intracellular parasite. Infection of a cell produces a unique niche for the parasite named the parasitophorous vacuole (PV) initially composed of host plasma membrane invaginated during invasion....