Marah C Runtsch
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Explore the profile of Marah C Runtsch including associated specialties, affiliations and a list of published articles.
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20
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2154
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Recent Articles
11.
Mills E, Ryan D, Prag H, Dikovskaya D, Menon D, Zaslona Z, et al.
Nature
. 2018 Mar;
556(7699):113-117.
PMID: 29590092
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for...
12.
Runtsch M, ONeill L
Cell Res
. 2017 Dec;
28(2):137-138.
PMID: 29192676
Long-noncoding RNAs (lncRNAs) are emerging as important regulators of cellular processes, but few have been functionally characterized in host-pathogen interactions. A recent report in Science demonstrates a mechanistic role for...
13.
Alexander M, Ramstead A, Bauer K, Lee S, Runtsch M, Wallace J, et al.
J Immunol
. 2017 Oct;
199(10):3559-3570.
PMID: 28978688
Extracellular vesicles, including exosomes, have recently been implicated as novel mediators of immune cell communication in mammals. However, roles for endogenously produced exosomes in regulating immune cell functions in vivo...
14.
Huffaker T, Lee S, Tang W, Wallace J, Alexander M, Runtsch M, et al.
J Biol Chem
. 2017 Sep;
292(45):18530-18541.
PMID: 28912267
MicroRNA-155 (miR-155) regulates antitumor immune responses. However, its specific functions within distinct immune cell types have not been delineated in conditional KO mouse models. In this study, we investigated the...
15.
Wallace J, Kagele D, Eiring A, Kim C, Hu R, Runtsch M, et al.
Blood
. 2017 Apr;
129(23):3074-3086.
PMID: 28432220
FLT3-ITD acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD AML compared...
16.
Runtsch M, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, et al.
Oncotarget
. 2015 Oct;
6(30):28556-72.
PMID: 26456940
Host-microbial interactions within the mammalian intestines must be properly regulated in order to promote host health and limit disease. Because the microbiota provide constant immunological signals to intestinal tissues, a...
17.
Alexander M, Hu R, Runtsch M, Kagele D, Mosbruger T, Tolmachova T, et al.
Nat Commun
. 2015 Jun;
6:7321.
PMID: 26084661
MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cells and mediate target gene...
18.
Hu R, Kagele D, Huffaker T, Runtsch M, Alexander M, Liu J, et al.
Immunity
. 2014 Nov;
41(4):605-19.
PMID: 25367574
Chronic inflammation is a contributing factor to most life-shortening human diseases. However, the molecular and cellular mechanisms that sustain chronic inflammatory responses remain poorly understood, making it difficult to treat...
19.
Runtsch M, Round J, OConnell R
Front Genet
. 2014 Oct;
5:347.
PMID: 25324861
The mammalian intestinal tract is a unique site in which a large portion of our immune system and the 10(14) commensal organisms that make up the microbiota reside in intimate...
20.
Hu R, Huffaker T, Kagele D, Runtsch M, Bake E, Chaudhuri A, et al.
J Immunol
. 2013 May;
190(12):5972-80.
PMID: 23686497
Th17 cells are central to the pathogenesis of autoimmune disease, and recently specific noncoding microRNAs have been shown to regulate their development. However, it remains unclear whether microRNAs are also...