Soh-Hyun Lee
Overview
Explore the profile of Soh-Hyun Lee including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
644
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0
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Recent Articles
1.
Tang W, Battistone B, Bauer K, Weis A, Barba C, Fadlullah M, et al.
Cell Rep
. 2025 Feb;
44(2):115301.
PMID: 39951377
The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of...
2.
Ghazaryan A, Wallace J, Tang W, Barba C, Lee S, Bauer K, et al.
Front Genet
. 2023 May;
14:1192799.
PMID: 37229187
Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML....
3.
Barba C, Ekiz H, Tang W, Ghazaryan A, Hansen M, Lee S, et al.
Cancers (Basel)
. 2023 Mar;
15(5).
PMID: 36900204
(1) Background: Immune cells infiltrate the tumor microenvironment and secrete inflammatory cytokines, including interferons (IFNs), to drive antitumor responses and promote tumor clearance. However, recent evidence suggests that sometimes, tumor...
4.
Bauer K, Nelson M, Tang W, Chiaro T, Brown D, Ghazaryan A, et al.
JCI Insight
. 2022 Oct;
7(19).
PMID: 36214220
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles...
5.
Huffaker T, Ekiz H, Barba C, Lee S, Runtsch M, Nelson M, et al.
Nat Commun
. 2021 May;
12(1):2620.
PMID: 33976173
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains...
6.
Ekiz H, Ramstead A, Lee S, Nelson M, Bauer K, Wallace J, et al.
J Immunol
. 2020 Mar;
204(8):2064-2075.
PMID: 32161096
Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation. In this study, we...
7.
Ramstead A, Wallace J, Lee S, Bauer K, Tang W, Ekiz H, et al.
Cell Rep
. 2020 Mar;
30(9):2889-2899.e6.
PMID: 32130894
Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting...
8.
Salaye L, Bychkova I, Sink S, Kovalic A, Bharadwaj M, Lorenzo F, et al.
Nutrients
. 2019 Sep;
11(9).
PMID: 31510077
High tissue iron levels are a risk factor for multiple chronic diseases including type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). To investigate causal relationships and underlying...
9.
Petersen C, Bell R, Klag K, Lee S, Soto R, Ghazaryan A, et al.
Science
. 2019 Jul;
365(6451).
PMID: 31346040
The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we observed the development of age-associated metabolic syndrome (MetS). Expansion of and loss...
10.
Runtsch M, Nelson M, Lee S, Voth W, Alexander M, Hu R, et al.
PLoS Genet
. 2019 Feb;
15(2):e1007970.
PMID: 30768595
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice....