Manus W Ward
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Explore the profile of Manus W Ward including associated specialties, affiliations and a list of published articles.
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26
Citations
691
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Recent Articles
1.
Weisova P, Anilkumar U, Ryan C, Concannon C, Prehn J, Ward M
Biochim Biophys Acta
. 2012 Feb;
1817(5):744-53.
PMID: 22336583
The preconditioning response conferred by a mild uncoupling of the mitochondrial membrane potential (Δψ(m)) has been attributed to altered reactive oxygen species (ROS) production and mitochondrial Ca(2+) uptake within the...
2.
DOrsi B, Bonner H, Tuffy L, Dussmann H, Woods I, Courtney M, et al.
J Neurosci
. 2012 Feb;
32(5):1847-58.
PMID: 22302823
Excitotoxicity resulting from excessive Ca(2+) influx through glutamate receptors contributes to neuronal injury after stroke, trauma, and seizures. Increased cytosolic Ca(2+) levels activate a family of calcium-dependent proteases with papain-like...
3.
Tsuchiya T, Bonner H, Engel T, Woods I, Matsushima S, Ward M, et al.
Eur J Neurosci
. 2011 Jan;
33(3):401-8.
PMID: 21198986
Bcl-2 homology domain 3 (BH3)-only proteins are pro-apoptotic Bcl-2 family members that play important roles in upstream cell death signalling during apoptosis. Proteasomal stress has been shown to contribute to...
4.
Tuffy L, Concannon C, DOrsi B, King M, Woods I, Huber H, et al.
Mol Cell Biol
. 2010 Oct;
30(23):5484-501.
PMID: 20921277
Proteasomal stress and the accumulation of polyubiquitinated proteins are key features of numerous neurodegenerative disorders. Previously we demonstrated that stabilization of p53 and activation of its target gene, puma (p53-upregulated...
5.
Kilbride S, Farrelly A, Bonner C, Ward M, Nyhan K, Concannon C, et al.
J Biol Chem
. 2010 Sep;
285(46):36199-206.
PMID: 20841353
Heterozygous loss-of-function mutations in the hepatocyte nuclear factor 1A (HNF1A) gene result in the pathogenesis of maturity-onset diabetes-of-the-young type 3, (HNF1A-MODY). This disorder is characterized by a primary defect in...
6.
Weisova P, Davila D, Tuffy L, Ward M, Concannon C, Prehn J
Antioxid Redox Signal
. 2010 Aug;
14(10):1863-76.
PMID: 20712420
5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has...
7.
Bonner C, Bacon S, Concannon C, Rizvi S, Baquie M, Farrelly A, et al.
Diabetes
. 2010 Aug;
59(11):2799-808.
PMID: 20682686
Objective: In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in...
8.
Zhdanov A, Ward M, Taylor C, Souslova E, Chudakov D, Prehn J, et al.
Biochim Biophys Acta
. 2010 Jun;
1797(9):1627-37.
PMID: 20550942
Fluctuating extracellular Ca2+ regulates many aspects of neuronal (patho)physiology including cell metabolism and respiration. Using fluorescence-based intracellular oxygen sensing technique, we demonstrate that depletion of extracellular Ca2+ from 1.8 to...
9.
Bonner H, Concannon C, Bonner C, Woods I, Ward M, Prehn J
J Neurochem
. 2010 May;
114(2):606-16.
PMID: 20477911
Proteasomal stress is believed to contribute to the pathology of ischemic brain injury and several neurodegenerative disorders, but can activate both cytoprotective and cell death-inducing pathways. Here we have utilized...
10.
Ward M, Concannon C, Whyte J, Walsh C, Corley B, Prehn J
J Neurochem
. 2010 Apr;
113(1):275-84.
PMID: 20405578
The amyloid precursor protein (APP) is critically involved in the pathogenesis of Alzheimer's disease, and is strongly up-regulated in response to traumatic, metabolic, or toxic insults to the nervous system....