Liam P Tuffy
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Explore the profile of Liam P Tuffy including associated specialties, affiliations and a list of published articles.
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10
Citations
414
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Recent Articles
1.
Altas B, Tuffy L, Patrizi A, Dimova K, Soykan T, Brandenburg C, et al.
Biol Psychiatry
. 2023 Dec;
96(10):815-828.
PMID: 38154503
Background: Neuroligin-3 is a postsynaptic adhesion molecule involved in synapse development and function. It is implicated in rare, monogenic forms of autism, and its shedding is critical to the tumor...
2.
Ripamonti S, Ambrozkiewicz M, Guzzi F, Gravati M, Biella G, Bormuth I, et al.
Elife
. 2017 Feb;
6.
PMID: 28231043
Beyond its role in parturition and lactation, oxytocin influences higher brain processes that control social behavior of mammals, and perturbed oxytocin signaling has been linked to the pathogenesis of several...
3.
Nolan K, Walter F, Tuffy L, Poeschel S, Gallagher R, Haunsberger S, et al.
Eur J Neurosci
. 2016 Jan;
43(5):640-52.
PMID: 26750440
Disturbance of homeostasis within the endoplasmic reticulum (ER) lumen leads to the accumulation of unfolded and misfolded proteins. This results in the activation of an evolutionary conserved stress response termed...
4.
Poulopoulos A, Soykan T, Tuffy L, Hammer M, Varoqueaux F, Brose N
Biochem J
. 2012 Jun;
446(2):321-30.
PMID: 22671294
Neuroligins are postsynaptic adhesion proteins involved in the establishment of functional synapses in the central nervous system. In rodents, four genes give rise to neuroligins that function at distinct synapses,...
5.
Krueger D, Tuffy L, Papadopoulos T, Brose N
Curr Opin Neurobiol
. 2012 Mar;
22(3):412-22.
PMID: 22424845
Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion proteins that play a key role in the formation, maturation, activity-dependent validation, and maintenance of synapses. As complex alternative splicing...
6.
DOrsi B, Bonner H, Tuffy L, Dussmann H, Woods I, Courtney M, et al.
J Neurosci
. 2012 Feb;
32(5):1847-58.
PMID: 22302823
Excitotoxicity resulting from excessive Ca(2+) influx through glutamate receptors contributes to neuronal injury after stroke, trauma, and seizures. Increased cytosolic Ca(2+) levels activate a family of calcium-dependent proteases with papain-like...
7.
Tuffy L, Concannon C, DOrsi B, King M, Woods I, Huber H, et al.
Mol Cell Biol
. 2010 Oct;
30(23):5484-501.
PMID: 20921277
Proteasomal stress and the accumulation of polyubiquitinated proteins are key features of numerous neurodegenerative disorders. Previously we demonstrated that stabilization of p53 and activation of its target gene, puma (p53-upregulated...
8.
Weisova P, Davila D, Tuffy L, Ward M, Concannon C, Prehn J
Antioxid Redox Signal
. 2010 Aug;
14(10):1863-76.
PMID: 20712420
5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has...
9.
Concannon C, Tuffy L, Weisova P, Bonner H, Davila D, Bonner C, et al.
J Cell Biol
. 2010 Mar;
189(1):83-94.
PMID: 20351066
Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, irreversible ATP depletion, whereas the ability to recover...
10.
Concannon C, Ward M, Bonner H, Kuroki K, Tuffy L, Bonner C, et al.
J Neurochem
. 2007 Dec;
105(3):891-903.
PMID: 18088354
Disruption of endoplasmic reticulum (ER) Ca2+ homeostasis and ER dysfunction have been suggested to contribute to excitotoxic and ischaemic neuronal injury. Previously, we have characterized the neural transcriptome following ER...