Manu Shukla
Overview
Explore the profile of Manu Shukla including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
344
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Recent Articles
1.
Torres-Garcia S, Huang Y, Dewornu F, Tong P, Yeboah R, Allshire R, et al.
Methods Mol Biol
. 2024 Nov;
2862:309-320.
PMID: 39527210
Eukaryotic DNA is organized in the nucleus in the form of chromatin. Nucleosomes, the fundamental unit of chromatin, are subject to many posttranslational modifications (PTMs) as well as compositional variations...
2.
Dewornu F, Tong P, Torres-Garcia S, Pidoux A, Allshire R, Shukla M
Methods Mol Biol
. 2024 Nov;
2862:255-266.
PMID: 39527206
Histone modifications and transcription factor-DNA interactions regulate vital processes such as transcription, recombination, repair, and accurate chromosome segregation. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been instrumental in studying genome-wide...
3.
Oveisi M, Shukla M, Seymen N, Ohno M, Taniguchi Y, Nahata S, et al.
Bioinformatics
. 2021 Oct;
37(23):4562-4563.
PMID: 34623394
Motivation: Deciphering nucleosome-nucleosome interactions is an important step toward mesoscale description of chromatin organization but computational tools to perform such analyses are not publicly available. Results: We developed iNucs, a...
4.
Tripathi V, Agrawal S, Shukla M, Pandey A
J Obstet Gynaecol India
. 2021 Jun;
71(2):210-212.
PMID: 34149229
No abstract available.
5.
Torres-Garcia S, Yaseen I, Shukla M, Audergon P, White S, Pidoux A, et al.
Nature
. 2020 Sep;
585(7825):453-458.
PMID: 32908306
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided...
6.
Singh P, Shukla M, White S, Lafos M, Tong P, Auchynnikava T, et al.
Genes Dev
. 2020 Jan;
34(3-4):226-238.
PMID: 31919190
Centromeres are maintained epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which directs kinetochore assembly and hence centromere function. To identify factors that promote assembly of...
7.
Tong P, Pidoux A, Toda N, Ard R, Berger H, Shukla M, et al.
Nat Commun
. 2019 May;
10(1):2343.
PMID: 31138803
Despite the conserved essential function of centromeres, centromeric DNA itself is not conserved. The histone-H3 variant, CENP-A, is the epigenetic mark that specifies centromere identity. Paradoxically, CENP-A normally assembles on...
8.
Shukla M, Tong P, White S, Singh P, Reid A, Catania S, et al.
Curr Biol
. 2018 Dec;
28(24):3924-3936.e4.
PMID: 30503616
Active centromeres are defined by the presence of nucleosomes containing CENP-A, a histone H3 variant, which alone is sufficient to direct kinetochore assembly. Once assembled at a location, CENP-A chromatin...
9.
Shukla M, Dos Santos R, Chen F, Lu C
Big Data
. 2017 Sep;
5(3):225-245.
PMID: 28933944
Storytelling connects entities (people, organizations) using their observed relationships to establish meaningful storylines. This can be extended to spatiotemporal storytelling that incorporates locations, time, and graph computations to enhance coherence...
10.
Audergon P, Catania S, Kagansky A, Tong P, Shukla M, Pidoux A, et al.
Science
. 2015 Apr;
348(6230):132-5.
PMID: 25838386
Posttranslational histone modifications are believed to allow the epigenetic transmission of distinct chromatin states, independently of associated DNA sequences. Histone H3 lysine 9 (H3K9) methylation is essential for heterochromatin formation;...