Alison L Pidoux
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Explore the profile of Alison L Pidoux including associated specialties, affiliations and a list of published articles.
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27
Citations
1454
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Recent Articles
1.
Yaseen I, White S, Torres-Garcia S, Spanos C, Lafos M, Gaberdiel E, et al.
Nat Struct Mol Biol
. 2022 Jul;
29(8):745-758.
PMID: 35879419
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an adaptive response allowing heterochromatin island formation that confers...
2.
Wu W, McHugh T, Kelly D, Pidoux A, Allshire R
Curr Biol
. 2022 Jul;
32(14):3121-3136.e6.
PMID: 35830853
The establishment of centromere-specific CENP-A chromatin is influenced by epigenetic and genetic processes. Central domain sequences from fission yeast centromeres are preferred substrates for CENP-A incorporation, but their use is...
3.
Torres-Garcia S, Di Pompeo L, Eivers L, Gaborieau B, White S, Pidoux A, et al.
Wellcome Open Res
. 2020 Dec;
5:274.
PMID: 33313420
The CRISPR/Cas9 system allows scarless, marker-free genome editing. Current CRISPR/Cas9 systems for the fission yeast rely on tedious and time-consuming cloning procedures to introduce a specific sgRNA target sequence into...
4.
Fitz-James M, Tong P, Pidoux A, Ozadam H, Yang L, White S, et al.
Elife
. 2020 Sep;
9.
PMID: 32915140
During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the...
5.
Torres-Garcia S, Yaseen I, Shukla M, Audergon P, White S, Pidoux A, et al.
Nature
. 2020 Sep;
585(7825):453-458.
PMID: 32908306
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided...
6.
Singh P, Shukla M, White S, Lafos M, Tong P, Auchynnikava T, et al.
Genes Dev
. 2020 Jan;
34(3-4):226-238.
PMID: 31919190
Centromeres are maintained epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which directs kinetochore assembly and hence centromere function. To identify factors that promote assembly of...
7.
Tong P, Pidoux A, Toda N, Ard R, Berger H, Shukla M, et al.
Nat Commun
. 2019 May;
10(1):2343.
PMID: 31138803
Despite the conserved essential function of centromeres, centromeric DNA itself is not conserved. The histone-H3 variant, CENP-A, is the epigenetic mark that specifies centromere identity. Paradoxically, CENP-A normally assembles on...
8.
Grech L, Jeffares D, Sadee C, Rodriguez-Lopez M, Bitton D, Hoti M, et al.
Mol Biol Evol
. 2019 May;
36(8):1612-1623.
PMID: 31077324
The relationship between DNA sequence, biochemical function, and molecular evolution is relatively well-described for protein-coding regions of genomes, but far less clear in noncoding regions, particularly, in eukaryote genomes. In...
9.
Shukla M, Tong P, White S, Singh P, Reid A, Catania S, et al.
Curr Biol
. 2018 Dec;
28(24):3924-3936.e4.
PMID: 30503616
Active centromeres are defined by the presence of nucleosomes containing CENP-A, a histone H3 variant, which alone is sufficient to direct kinetochore assembly. Once assembled at a location, CENP-A chromatin...
10.
Yadav R, Jablonowski C, Fernandez A, Lowe B, Henry R, Finkelstein D, et al.
Elife
. 2017 Jul;
6.
PMID: 28718400
Recurrent somatic mutations of in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific...