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Manpreet Kaur Rawal

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Articles 17
Citations 148
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Redhu A, Banerjee A, Shah A, Moreno A, Rawal M, Nair R, et al.
J Mol Biol . 2018 Jan; 430(5):682-694. PMID: 29341887
The molecular basis of polyspecificity of Mdr1p, a major drug/H antiporter of Candida albicans, is not elucidated. We have probed the nature of the drug-binding pocket by performing systematic mutagenesis...
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Baghel P, Rawal M, Khan M, Sen S, Siddiqui M, Chaptal V, et al.
Biochim Biophys Acta Biomembr . 2017 Jun; 1859(10):1778-1789. PMID: 28559186
The present study examines the kinetics of steroids efflux mediated by the Candida drug resistance protein 1 (Cdr1p) and evaluates their interaction with the protein. We exploited our in-house mutant...
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Monico A, Nim S, Duarte N, Rawal M, Prasad R, Di Pietro A, et al.
Bioorg Med Chem . 2017 May; 25(13):3278-3284. PMID: 28479022
Macrocyclic diterpenes were previously found to be able to modulate the efflux pump activity of Candida albicans multidrug transporters. Most of these compounds were jatrophanes, but only a few number...
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Esposito M, Nim S, Nothias L, Gallard J, Rawal M, Costa J, et al.
J Nat Prod . 2017 Jan; 80(2):479-487. PMID: 28106996
Twenty-nine jatrophane esters (1-10, 12-30) and one lathyrane (11) diterpenoid ester isolated from Euphorbia species were evaluated for their capacity to inhibit drug-efflux activities of the primary ABC transporter CaCdr1p...
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Nim S, Lobato L, Moreno A, Chaptal V, Rawal M, Falson P, et al.
Biochim Biophys Acta . 2016 Aug; 1858(11):2858-2870. PMID: 27569110
The ABC (ATP-Binding Cassette) transporter Cdr1 (Candida drug resistance 1) protein (Cdr1p) of Candida albicans, shows promiscuity towards the substrate it exports and plays a major role in antifungal resistance....
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Rawal M, Banerjee A, Shah A, Khan M, Sen S, Saxena A, et al.
Sci Rep . 2016 Jul; 6:30221. PMID: 27452273
No abstract available.
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Rawal M, Banerjee A, Shah A, Khan M, Sen S, Saxena A, et al.
Sci Rep . 2016 Jun; 6:27132. PMID: 27251950
An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence of these motifs in ABC subfamilies of...
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Nim S, Monico A, Rawal M, Duarte N, Prasad R, Di Pietro A, et al.
Planta Med . 2016 May; 82(13):1180-5. PMID: 27145238
Thirteen macrocyclic diterpenes (1-13) of the jatrophane and lathyrane types, either isolated from Euphorbia species or obtained by chemical derivatization, were evaluated for their ability to inhibit the drug efflux...
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Prasad R, Rawal M, Shah A
Adv Exp Med Biol . 2016 Jan; 892:351-376. PMID: 26721282
An enhanced expression of genes encoding ATP binding cassette (ABC) and major facilitator superfamily (MFS) transport proteins are known to contribute to the development of tolerance to antifungals in pathogenic...