Manon Eckhardt
Overview
Explore the profile of Manon Eckhardt including associated specialties, affiliations and a list of published articles.
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26
Citations
3423
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Recent Articles
1.
Serrano L, Pelin A, Arrey T, Damoc N, Richards A, Zhou Y, et al.
J Proteome Res
. 2025 Mar;
PMID: 40025722
Classical proteomics experiments offer high-throughput protein quantification but lack direct evidence of the spatial organization of the proteome, including protein-protein interaction (PPIs) networks. While affinity purification mass spectrometry (AP-MS) is...
2.
Turnham R, Pitea A, Jang G, Xu Z, Lim H, Choi A, et al.
Cancer Res
. 2024 Dec;
85(4):660-674.
PMID: 39652575
Hepatitis B virus (HBV) infections promote liver cancer initiation by inducing inflammation and cellular stress. Despite a primarily indirect effect on oncogenesis, HBV is associated with a recurrent genomic phenotype...
3.
Kaushal P, Ummadi M, Jang G, Delgado Y, Makanani S, Alba K, et al.
STAR Protoc
. 2024 Nov;
5(4):103286.
PMID: 39488835
Proteins congregate into complexes to perform diverse cellular functions. Protein complexes are remodeled by protein-coding mutations or cellular signaling changes, driving phenotypic outcomes in health and disease. We present an...
4.
Zhong X, Li Q, Polacco B, Patil T, Marley A, Foussard H, et al.
Mol Syst Biol
. 2024 Jul;
20(8):952-971.
PMID: 38951684
Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow minimizing hands-on time and enhancing quantitative reproducibility. We introduced a...
5.
Kaushal P, Ummadi M, Jang G, Delgado Y, Makanani S, Blanc S, et al.
ArXiv
. 2024 May;
PMID: 38800652
Proteins congregate into complexes to perform fundamental cellular functions. Phenotypic outcomes, in health and disease, are often mechanistically driven by the remodeling of protein complexes by protein-coding mutations or cellular...
6.
Rathore U, Haas P, Kumar V, Hiatt J, Haas K, Bouhaddou M, et al.
mBio
. 2024 Feb;
15(4):e0222223.
PMID: 38411080
Importance: HIV, the virus that causes AIDS, heavily relies on the machinery of human cells to infect and replicate. Our study focuses on the host cell's ubiquitination system which is...
7.
Wang B, Vartak R, Zaltsman Y, Naing Z, Hennick K, Polacco B, et al.
bioRxiv
. 2023 Dec;
PMID: 38076945
Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes,...
8.
Haas K, McGregor M, Bouhaddou M, Polacco B, Kim E, Nguyen T, et al.
Nat Commun
. 2023 Sep;
14(1):6030.
PMID: 37758692
Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs)....
9.
Bouhaddou M, Reuschl A, Polacco B, Thorne L, Ummadi M, Ye C, et al.
Cell
. 2023 Sep;
186(21):4597-4614.e26.
PMID: 37738970
SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used unbiased systems approaches to study the host-selective forces driving VOC evolution. We discovered that VOCs evolved convergent...
10.
Olwal C, Fabius J, Zuliani-Alvarez L, Eckhardt M, Kyei G, Quashie P, et al.
Mol Omics
. 2023 May;
19(7):538-551.
PMID: 37204043
Women coinfected with human immunodeficiency virus type 1 (HIV-1) and human papillomavirus (HPV) are six times as likely to develop invasive cervical carcinoma compared to those without HIV. Unlike other...