Manon Eckhardt
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Explore the profile of Manon Eckhardt including associated specialties, affiliations and a list of published articles.
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26
Citations
3423
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Recent Articles
11.
Zhong X, Li Q, Polacco B, Patil T, Marley A, Foussard H, et al.
bioRxiv
. 2023 Apr;
PMID: 37090610
Proximity labeling (PL) through biotinylation coupled with mass spectrometry (MS) has emerged as a powerful technique for capturing spatial proteomes within living cells. Large-scale sample processing for proximity proteomics requires...
12.
Cakir Z, Lord S, Zhou Y, Jang G, Polacco B, Eckhardt M, et al.
Mol Cell Proteomics
. 2023 Apr;
22(5):100541.
PMID: 37019383
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE...
13.
Peters C, Schulze-Gahmen U, Eckhardt M, Jang G, Xu J, Pulido E, et al.
Nat Commun
. 2022 Sep;
13(1):5282.
PMID: 36075902
Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed therapies present an enticing option for this diverse genus of viruses....
14.
Richards A, Eckhardt M, Krogan N
Mol Syst Biol
. 2021 Jan;
17(1):e8792.
PMID: 33434350
A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease mechanisms are often mediated by interactions between proteins. Insights into...
15.
Gordon D, Hiatt J, Bouhaddou M, Rezelj V, Ulferts S, Braberg H, et al.
Science
. 2020 Oct;
370(6521).
PMID: 33060197
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more...
16.
Gordon D, Jang G, Bouhaddou M, Xu J, Obernier K, OMeara M, et al.
bioRxiv
. 2020 Jun;
PMID: 32511329
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, and caused worldwide...
17.
Tutuncuoglu B, Cakir M, Batra J, Bouhaddou M, Eckhardt M, Gordon D, et al.
Cancer Discov
. 2020 May;
10(7):916-921.
PMID: 32444466
The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus...
18.
Gordon D, Jang G, Bouhaddou M, Xu J, Obernier K, White K, et al.
Nature
. 2020 May;
583(7816):459-468.
PMID: 32353859
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to...
19.
Eckhardt M, Hultquist J, Kaake R, Huttenhain R, Krogan N
Nat Rev Genet
. 2020 Feb;
21(6):339-354.
PMID: 32060427
Ongoing social, political and ecological changes in the 21st century have placed more people at risk of life-threatening acute and chronic infections than ever before. The development of new diagnostic,...
20.
Bouhaddou M, Eckhardt M, Naing Z, Kim M, Ideker T, Krogan N
Curr Opin Genet Dev
. 2019 Jul;
54:110-117.
PMID: 31288129
Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of 'hallmark cancer pathways'. However, unraveling how sets of...