Jiewei Xu
Overview
Explore the profile of Jiewei Xu including associated specialties, affiliations and a list of published articles.
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45
Citations
4065
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Recent Articles
1.
Steiner W, Iverson N, Venkatakrishnan V, Wu J, Stepniewski T, Michaelson Z, et al.
bioRxiv
. 2024 Nov;
PMID: 39554190
The Hedgehog (Hh) signaling pathway is fundamental to embryogenesis, tissue homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon agonist-induced phosphorylation, the noncanonical G protein-coupled receptor SMOOTHENED...
2.
Kaushal P, Ummadi M, Jang G, Delgado Y, Makanani S, Alba K, et al.
STAR Protoc
. 2024 Nov;
5(4):103286.
PMID: 39488835
Proteins congregate into complexes to perform diverse cellular functions. Protein complexes are remodeled by protein-coding mutations or cellular signaling changes, driving phenotypic outcomes in health and disease. We present an...
3.
Zhong X, Li Q, Polacco B, Patil T, Marley A, Foussard H, et al.
Mol Syst Biol
. 2024 Jul;
20(8):952-971.
PMID: 38951684
Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow minimizing hands-on time and enhancing quantitative reproducibility. We introduced a...
4.
Kaushal P, Ummadi M, Jang G, Delgado Y, Makanani S, Blanc S, et al.
ArXiv
. 2024 May;
PMID: 38800652
Proteins congregate into complexes to perform fundamental cellular functions. Phenotypic outcomes, in health and disease, are often mechanistically driven by the remodeling of protein complexes by protein-coding mutations or cellular...
5.
Xu J, Qiu J
Altern Ther Health Med
. 2024 May;
PMID: 38758153
Context: Gastric cancer (GC) is a common and life-threatening gastrointestinal malignancy. Although mucin 3A (MUC3A) is an essential oncogenic factor in several cancers, limited information is available on its expression...
6.
Polacco B, Lobingier B, Blythe E, Abreu N, Khare P, Howard M, et al.
Nat Chem Biol
. 2024 Mar;
20(9):1133-1143.
PMID: 38528119
The μ-opioid receptor (μOR) represents an important target of therapeutic and abused drugs. So far, most understanding of μOR activity has focused on a subset of known signal transducers and...
7.
Wang B, Vartak R, Zaltsman Y, Naing Z, Hennick K, Polacco B, et al.
bioRxiv
. 2023 Dec;
PMID: 38076945
Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes,...
8.
Bouhaddou M, Reuschl A, Polacco B, Thorne L, Ummadi M, Ye C, et al.
Cell
. 2023 Sep;
186(21):4597-4614.e26.
PMID: 37738970
SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used unbiased systems approaches to study the host-selective forces driving VOC evolution. We discovered that VOCs evolved convergent...
9.
Zhong X, Li Q, Polacco B, Patil T, Marley A, Foussard H, et al.
bioRxiv
. 2023 Apr;
PMID: 37090610
Proximity labeling (PL) through biotinylation coupled with mass spectrometry (MS) has emerged as a powerful technique for capturing spatial proteomes within living cells. Large-scale sample processing for proximity proteomics requires...
10.
Hu X, Dong R, Huang S, Zeng Y, Zhan W, Gao X, et al.
Antimicrob Agents Chemother
. 2023 Apr;
67(5):e0170422.
PMID: 37052498
Clostridioides difficile infection (CDI) causes severe diarrhea and colitis, leading to significant morbidity, mortality, and high medical costs worldwide. Oral vancomycin, a first-line treatment for CDI, is associated with a...