Manon C A Pronk
Overview
Explore the profile of Manon C A Pronk including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
67
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Recent Articles
1.
Botros L, Pronk M, Juschten J, Liddle J, Morsing S, van Buul J, et al.
J Cell Sci
. 2020 Mar;
133(9).
PMID: 32198280
Endothelial barrier dysfunction leads to edema and vascular leak, causing high morbidity and mortality. Previously, Abl kinase inhibition has been shown to protect against vascular leak. Using the distinct inhibitory...
2.
CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity
Majolee J, Pronk M, Jim K, van Bezu J, van der Sar A, Hordijk P, et al.
Sci Rep
. 2019 Jun;
9(1):8131.
PMID: 31148579
RhoGTPases regulate cytoskeletal dynamics, migration and cell-cell adhesion in endothelial cells. Besides regulation at the level of guanine nucleotide binding, they also undergo post-translational modifications, for example ubiquitination. RhoGTPases are...
3.
Pronk M, Majolee J, Loregger A, van Bezu J, Zelcer N, Hordijk P, et al.
Mol Biol Cell
. 2019 Jan;
30(5):607-621.
PMID: 30601691
Rho GTPases control both the actin cytoskeleton and adherens junction stability and are recognized as essential regulators of endothelial barrier function. They act as molecular switches and are primarily regulated...
4.
Pronk M, van Bezu J, van Nieuw Amerongen G, van Hinsbergh V, Hordijk P
Small GTPases
. 2017 Sep;
10(6):466-484.
PMID: 28949796
RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator of endothelial barrier function, however...