Manish Shanker
Overview
Explore the profile of Manish Shanker including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
238
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0
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Recent Articles
1.
Shanker M, Willcutts D, Roth J, Ramesh R
Lung Cancer (Auckl)
. 2017 Feb;
1:23-36.
PMID: 28210104
Resistance to chemotherapy drugs is a major problem in cancer treatment. Scientific advances made in the last two decades have resulted in the identification of genes and molecular signaling mechanisms...
2.
Panneerselvam J, Shanker M, Jin J, Branch C, Muralidharan R, Zhao Y, et al.
Oncotarget
. 2015 May;
6(18):16271-86.
PMID: 26009991
Interleukin (IL)-24 is a tumor suppressor/cytokine gene that undergoes post-translational modifications (PTMs). Glycosylation and ubiquitination are important for IL-24 protein stabilization and degradation respectively. Little is known about IL-24 protein...
3.
Panneerselvam J, Jin J, Shanker M, Lauderdale J, Bates J, Wang Q, et al.
PLoS One
. 2015 Mar;
10(3):e0122439.
PMID: 25775124
Background: The stromal cell derived factor (SDF)-1/chemokine receptor (CXCR)-4 signaling pathway plays a key role in lung cancer metastasis and is molecular target for therapy. In the present study we...
4.
Babu A, Wang Q, Muralidharan R, Shanker M, Munshi A, Ramesh R
Mol Pharm
. 2014 Jun;
11(8):2720-33.
PMID: 24922589
Development of resistance toward anticancer drugs results in ineffective therapy leading to increased mortality. Therefore, overriding resistance and restoring sensitivity to anticancer drugs will improve treatment efficacy and reduce mortality....
5.
Yokoyama T, Tam J, Kuroda S, Scott A, Aaron J, Larson T, et al.
PLoS One
. 2011 Nov;
6(11):e25507.
PMID: 22087216
Background: The epidermal growth factor receptor (EGFR) is overexpressed in 80% of non-small cell lung cancer (NSCLC) and is associated with poor survival. In recent years, EGFR-targeted inhibitors have been...
6.
Shanker M, Jin J, Branch C, Miyamoto S, Grimm E, Roth J, et al.
J Drug Deliv
. 2011 Apr;
2011:465845.
PMID: 21490751
Cancer is a major health problem in the world. Advances made in cancer therapy have improved the survival of patients in certain types of cancer. However, the overall five-year survival...
7.
Shanker M, Gopalan B, Patel S, Bocangel D, Chada S, Ramesh R
Cancer Lett
. 2007 Apr;
254(2):217-26.
PMID: 17449172
Adenovirus-mediated mda-7 (Ad-mda7) gene transfer has been shown to induce apoptosis in various human cancer cells while sparing normal cells. Vitamin E succinate (VES) is also known to exhibit antitumor...
8.
Gopalan B, Shanker M, Chada S, Ramesh R
Mol Cancer
. 2007 Feb;
6:11.
PMID: 17274815
Background: Previous studies showed that the human melanoma differentiation-associated gene-7 (mda-7), also known as interleukin-24 (IL-24), has potent antitumor activity against human and murine cancer cells. However, the majority of...
9.
Inoue S, Shanker M, Miyahara R, Gopalan B, Patel S, Oida Y, et al.
Curr Gene Ther
. 2006 Feb;
6(1):73-91.
PMID: 16475947
Despite recent advances in treatment strategies, the overall 5-year survival rate for patients with common epithelial cancers is poor largely because of the difficulty in treating metastatic cancers. Therefore, therapeutic...
10.
Saito Y, Miyahara R, Gopalan B, Litvak A, Inoue S, Shanker M, et al.
Cancer Gene Ther
. 2004 Dec;
12(3):238-47.
PMID: 15578066
We have previously reported that overexpression of the melanoma differentiation-associated gene -7 (mda-7) using a replication-defective adenovirus (Ad-mda7), results in tumor-specific growth suppression and induction of apoptosis in wide variety...