Maniselvan Kuppusamy
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Explore the profile of Maniselvan Kuppusamy including associated specialties, affiliations and a list of published articles.
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28
Citations
367
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Recent Articles
1.
Ta H, Kuppusamy M, Sonkusare S, Roeser M, Laubach V
Respir Res
. 2024 Apr;
25(1):172.
PMID: 38637760
The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung...
2.
Ayon R, Kuppusamy M, Ceolotto G, Chen Y
Front Physiol
. 2024 Mar;
15:1375432.
PMID: 38482192
No abstract available.
3.
Kuppusamy M, Ta H, Davenport H, Bazaz A, Kulshrestha A, Daneva Z, et al.
Sci Signal
. 2023 Oct;
16(808):eadg1553.
PMID: 37874885
Lung ischemia-reperfusion injury (IRI), characterized by inflammation, vascular permeability, and lung edema, is the major cause of primary graft dysfunction after lung transplantation. Here, we investigated the cellular mechanisms underlying...
4.
Kuppusamy M, Ta H, Davenport H, Bazaz A, Kulshrestha A, Daneva Z, et al.
bioRxiv
. 2023 Jul;
PMID: 37397979
Lung ischemia-reperfusion injury (IRI), characterized by inflammation, vascular permeability, and lung edema, is the major cause of primary graft dysfunction after lung transplantation. We recently reported that endothelial cell (EC)...
5.
Wong D, Auguste G, Lino Cardenas C, Turner A, Chen Y, Song Y, et al.
Circ Res
. 2023 Apr;
132(9):1144-1161.
PMID: 37017084
Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for...
6.
Ruddiman C, Peckham R, Luse M, Chen Y, Kuppusamy M, Corliss B, et al.
JCI Insight
. 2023 Apr;
8(9).
PMID: 37014698
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular...
7.
Daneva Z, Kuppusamy M
Curr Top Membr
. 2022 Oct;
89:1-41.
PMID: 36210146
The delicate balance between constrictor and dilator mechanisms is a vital determinant of blood pressure and blood flow. The maintenance of this balance requires constant communication between different cell-types in...
8.
Chen Y, Daneva Z, Kuppusamy M, Ottolini M, Baker T, Klimentova E, et al.
Circulation
. 2022 Jun;
146(7):548-564.
PMID: 35758040
Background: Ca signals in smooth muscle cells (SMCs) contribute to vascular resistance and control blood pressure. Increased vascular resistance in hypertension has been attributed to impaired SMC Ca signaling mechanisms....
9.
Ali Y, Kuppusamy M, Velarde-Miranda C, Gomez-Sanchez C, Plonczynski M, Gomez-Sanchez C, et al.
J Endocr Soc
. 2021 Sep;
5(11):bvab146.
PMID: 34568711
Affinity of the mineralocorticoid receptor (MR) is similar for aldosterone and the glucocorticoids (GC) cortisol and corticosterone, which circulate at concentrations far exceeding those of aldosterone. 11β-hydroxysteroid dehydrogenase type 2...
10.
Kuppusamy M, Ottolini M, Sonkusare S
Neurosci Lett
. 2021 Sep;
765:136258.
PMID: 34560190
The dynamic regulation of blood flow is essential for meeting the high metabolic demands of the brain and maintaining brain function. Cerebral blood flow is regulated primarily by 1) the...