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Maniselvan Kuppusamy

Explore the profile of Maniselvan Kuppusamy including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 367
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Recent Articles
11.
Daneva Z, Ottolini M, Chen Y, Klimentova E, Kuppusamy M, Shah S, et al.
Elife . 2021 Sep; 10. PMID: 34490843
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor...
12.
Daneva Z, Marziano C, Ottolini M, Chen Y, Baker T, Kuppusamy M, et al.
Proc Natl Acad Sci U S A . 2021 Apr; 118(17). PMID: 33879616
Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and lung injury. However, in pulmonary hypertension (PH), small pulmonary arteries are...
13.
Pabbidi M, Kuppusamy M, Didion S, Sanapureddy P, Reed J, Sontakke S
Am J Physiol Heart Circ Physiol . 2018 Sep; 315(6):H1499-H1518. PMID: 30192631
The incidence of cardiovascular disease (CVD) is lower in premenopausal women but increases with age and menopause compared with similarly aged men. Based on the prevalence of CVD in postmenopausal...
14.
Lenzini L, Prisco S, Gallina M, Kuppusamy M, Rossi G
Endocrinology . 2018 Jan; 159(3):1352-1359. PMID: 29293917
Because blunted expression of the twik-related acid-sensitive K+ channel 2 (TASK-2) is a common feature of aldosterone-producing adenoma (APA) causing primary aldosteronism (PA), we sequenced the promoter region of the...
15.
Gomez-Sanchez C, Kuppusamy M, Reincke M, Williams T
Horm Metab Res . 2017 Dec; 49(12):957-962. PMID: 29202495
Primary aldosteronism is the most common type of secondary hypertension affecting 6-10% of patients with primary hypertension. PA is mainly caused by unilateral hyperaldosteronism due to an aldosterone-producing adenoma, unilateral...
16.
Ceolotto G, Giannella A, Albiero M, Kuppusamy M, Radu C, Simioni P, et al.
Cardiovasc Res . 2017 Oct; 113(13):1627-1638. PMID: 29016810
Aims: Atherosclerosis is an inflammatory disease wherein cholesterol-loaded macrophages play a major role. MicroRNAs and microparticles propagate inflammatory pathways and are involved in cardiovascular disease. We aimed to screen and...
17.
Gomez-Sanchez C, Lewis M, Nanba K, Rainey W, Kuppusamy M, Gomez-Sanchez E
Steroids . 2017 Sep; 127:56-61. PMID: 28863887
The human 3β-hydroxysteroid dehydrogenase/isomerase (HSD3B) enzymes catalyze the conversion of 3β-hydroxy Δ5-6 steroids into 3-keto Δ4-5 steroids, which is required for the synthesis of the mature steroid hormones secreted by...
18.
Gomez-Sanchez C, Kuppusamy M, Gomez-Sanchez E
Hypertension . 2017 Jun; 70(2):240-242. PMID: 28630207
No abstract available.
19.
Kuppusamy M, Gomez-Sanchez E, Beloate L, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, et al.
Endocrinology . 2017 May; 158(7):2367-2375. PMID: 28472300
The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various...
20.
Cattelan A, Ceolotto G, Bova S, Albiero M, Kuppusamy M, De Martin S, et al.
Vascul Pharmacol . 2015 Apr; 70:35-44. PMID: 25863291
Ischemia-reperfusion (IR) leads to severe organ injury and dysfunction. Sirtuins (SIRTs) are a family of histone deacetylases (HDACs) that require nicotinamide adenine dinucleotide (NAD(+)) for the deacetylation reaction. SIRTs play...