Manira Rayamajhi
Overview
Explore the profile of Manira Rayamajhi including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
984
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Recent Articles
1.
Korkaya A, Fischer J, Peppers A, Crosson S, Rayamajhi M, Miao E, et al.
Innate Immun
. 2023 Oct;
29(8):171-185.
PMID: 37828842
Here, we describe the production and characterization of a novel p65/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone...
2.
Nozaki K, Maltez V, Rayamajhi M, Tubbs A, Mitchell J, Lacey C, et al.
Nature
. 2022 Jun;
606(7916):960-967.
PMID: 35705808
Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin...
3.
Jorgensen I, Rayamajhi M, Miao E
Nat Rev Immunol
. 2017 Feb;
17(3):151-164.
PMID: 28138137
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we...
4.
Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al.
PLoS Pathog
. 2016 Aug;
12(8):e1005803.
PMID: 27482714
Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales can be used...
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Rayamajhi M, Miao E
Nat Immunol
. 2014 Nov;
15(12):1100-2.
PMID: 25396345
Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of...
8.
Rayamajhi M, Miao E, Moorman N
Cell
. 2014 Feb;
156(4):629-30.
PMID: 24529369
The functional significance of protein diversification through translational regulation in mammals is largely unexplored. Brubaker et al. now describe the generation of two functionally distinct mammalian proteins, MAVS and miniMAVS,...
9.
Rayamajhi M, Zak D, Chavarria-Smith J, Vance R, Miao E
J Immunol
. 2013 Sep;
191(8):3986-9.
PMID: 24043898
The NAIP/NLRC4 inflammasomes activate caspase-1 in response to bacterial type III secretion systems (T3SSs). Inadvertent injection of the T3SS rod protein and flagellin into the cytosol is detected through murine...
10.
Rayamajhi M, Zhang Y, Miao E
Methods Mol Biol
. 2013 Jul;
1040:85-90.
PMID: 23852598
Pyroptosis is a form of programmed, inflammatory cell death that is dependent on the activation of a cysteine protease caspase-1. Following caspase-1 activation via inflammasomes (including NLRP3, NLRC4, Nlrp1b, and...