Manfred Schmid
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Explore the profile of Manfred Schmid including associated specialties, affiliations and a list of published articles.
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42
Citations
1107
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Recent Articles
1.
Wu G, Rouviere J, Schmid M, Jensen T
Nat Commun
. 2024 Dec;
15(1):10446.
PMID: 39617768
Premature transcription termination yields a wealth of unadenylated (pA) RNA. Although this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex, possible backup pathways remain poorly understood....
2.
Imamura K, Garland W, Schmid M, Jakobsen L, Sato K, Rouviere J, et al.
Mol Cell
. 2024 Nov;
84(21):4158-4174.e6.
PMID: 39515294
In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show that 5' flanking regions,...
3.
Lykke-Andersen S, Rouviere J, Schmid M, Gockert M, Jensen T
STAR Protoc
. 2024 Mar;
5(2):102960.
PMID: 38502686
The widespread usage of next-generation sequencing methods for functional genomics studies requires standardized tools for consistent visualization of the associated data. Here, we present seqNdisplayR, an R package for plotting...
4.
Polak P, Garland W, Rathore O, Schmid M, Salerno-Kochan A, Jakobsen L, et al.
Cell Rep
. 2023 Oct;
42(11):113325.
PMID: 37889751
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting...
5.
Rouviere J, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, et al.
Mol Cell
. 2023 Jun;
83(13):2240-2257.e6.
PMID: 37329882
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII) transcription termination and transcript decay. Despite its essential nature, the mechanisms by which ARS2 enacts these...
6.
Wu M, Schmid M, Jensen T, Sandelin A
NAR Genom Bioinform
. 2022 Sep;
4(3):lqac071.
PMID: 36128426
The RNA exosome degrades transcripts in the nucleoplasm of mammalian cells. Its substrate specificity is mediated by two adaptors: the 'nuclear exosome targeting (NEXT)' complex and the 'poly(A) exosome targeting...
7.
Rittinghaus S, Jagle E, Schmid M, Gokce B
Materials (Basel)
. 2022 Sep;
15(17).
PMID: 36079549
Laser-based additive manufacturing (LAM) in all its variations is now being established as a technique for manufacturing components from various material types and alloys [...].
8.
Garland W, Muller I, Wu M, Schmid M, Imamura K, Rib L, et al.
Mol Cell
. 2022 Mar;
82(9):1691-1707.e8.
PMID: 35349793
Transposable elements (TEs) are widespread genetic parasites known to be kept under tight transcriptional control. Here, we describe a functional connection between the mouse-orthologous "nuclear exosome targeting" (NEXT) and "human...
9.
Gockert M, Schmid M, Jakobsen L, Jens M, Andersen J, Jensen T
Nucleic Acids Res
. 2022 Jan;
50(3):1583-1600.
PMID: 35048984
Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly(A) tail eXosome Targeting (PAXT) connection. Functional...
10.
Sillani F, Schiegg R, Schmid M, MacDonald E, Wegener K
Polymers (Basel)
. 2022 Jan;
14(1).
PMID: 35012103
Powder bed fusion of polymers is becoming increasingly adopted by a variety of industries to tailor the strength, weight and functionality of end-use products. To meet the high standards of...