Jerome O Rouviere
Overview
Explore the profile of Jerome O Rouviere including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
166
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Recent Articles
1.
Wu G, Rouviere J, Schmid M, Jensen T
Nat Commun
. 2024 Dec;
15(1):10446.
PMID: 39617768
Premature transcription termination yields a wealth of unadenylated (pA) RNA. Although this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex, possible backup pathways remain poorly understood....
2.
Imamura K, Garland W, Schmid M, Jakobsen L, Sato K, Rouviere J, et al.
Mol Cell
. 2024 Nov;
84(21):4158-4174.e6.
PMID: 39515294
In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show that 5' flanking regions,...
3.
Davidson L, Rouviere J, Sousa-Luis R, Nojima T, Proudfoot N, Jensen T, et al.
Genes Dev
. 2024 Nov;
38(21-24):998-1019.
PMID: 39496457
The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII...
4.
Garland W, Rouviere J, Jensen T
Mol Cell
. 2024 Jul;
84(13):2405-2406.
PMID: 38996456
In this issue of Molecular Cell, Razew et al. and Sabath et al. assign function to an unexplored module of the Integrator (INT) complex, expanding the toolbox of this genome-wide...
5.
Lykke-Andersen S, Rouviere J, Schmid M, Gockert M, Jensen T
STAR Protoc
. 2024 Mar;
5(2):102960.
PMID: 38502686
The widespread usage of next-generation sequencing methods for functional genomics studies requires standardized tools for consistent visualization of the associated data. Here, we present seqNdisplayR, an R package for plotting...
6.
Rouviere J, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, et al.
Mol Cell
. 2023 Jun;
83(13):2240-2257.e6.
PMID: 37329882
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII) transcription termination and transcript decay. Despite its essential nature, the mechanisms by which ARS2 enacts these...
7.
Rouviere J, Lykke-Andersen S, Jensen T
Biochem Soc Trans
. 2022 Feb;
50(1):283-295.
PMID: 35166324
Transcription establishes the universal first step of gene expression where RNA is produced by a DNA-dependent RNA polymerase. The most versatile of eukaryotic RNA polymerases, RNA polymerase II (Pol II),...
8.
Lykke-Andersen S, Rouviere J, Jensen T
Biochem Soc Trans
. 2021 Jun;
49(3):1325-1336.
PMID: 34060620
ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with...
9.
Lautier O, Penzo A, Rouviere J, Chevreux G, Collet L, Loiodice I, et al.
Mol Cell
. 2021 Apr;
81(11):2417-2427.e5.
PMID: 33838103
mRNA translation is coupled to multiprotein complex assembly in the cytoplasm or to protein delivery into intracellular compartments. Here, by combining systematic RNA immunoprecipitation and single-molecule RNA imaging in yeast,...
10.
Lykke-Andersen S, Zumer K, Molska E, Rouviere J, Wu G, Demel C, et al.
Mol Cell
. 2021 Jan;
81(3):514-529.e6.
PMID: 33385327
Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act at the ends of protein-coding...