Manfred Kraus
Overview
Explore the profile of Manfred Kraus including associated specialties, affiliations and a list of published articles.
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25
Citations
963
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Recent Articles
1.
Lee C, Jiang Z, Planken S, Manzuk L, Ortiz R, Hall M, et al.
Mol Cancer Ther
. 2023 May;
22(7):891-900.
PMID: 37186518
KRAS is one of the most commonly mutated oncogenes in lung, colorectal, and pancreatic cancers. Recent clinical trials directly targeting KRAS G12C presented encouraging results for a large population of...
2.
Gallego R, Bernier L, Chen H, Cho-Schultz S, Chung L, Collins M, et al.
J Med Chem
. 2023 Mar;
66(7):4888-4909.
PMID: 36940470
Immune activating agents represent a valuable class of therapeutics for the treatment of cancer. An area of active research is expanding the types of these therapeutics that are available to...
3.
Cordero F, Kraus M, Lin G, Ruf M, Zeng M
Phys Rev Lett
. 2023 Jan;
130(2):021601.
PMID: 36706419
We compute the conservative two-body Hamiltonian of a compact binary system with a spinning black hole through O(G^{3}) to all orders in velocity, including linear and quadratic spin terms. To...
4.
Kung P, Fan C, Gukasyan H, Huang B, Kephart S, Kraus M, et al.
J Med Chem
. 2021 Feb;
64(3):1725-1732.
PMID: 33529029
A pyridone-derived phosphate prodrug of an enhancer of zeste homolog 2 (EZH2) inhibitor was designed and synthesized to improve the inhibitor's aqueous solubility. This prodrug (compound ) was profiled in...
5.
Bartlett D, Wu A, Li X, Kraus M, Wang H, Kindt E
J Pharm Sci
. 2019 May;
108(9):3124-3129.
PMID: 31136767
Microdialysis is a technique that utilizes a semipermeable membrane to sample analytes present within tissue interstitial fluid. Analyte-specific calibration is required for quantitative microdialysis, but these calibration methods are tedious,...
6.
Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, et al.
Mol Cancer Ther
. 2018 Sep;
17(12):2530-2542.
PMID: 30232146
Tumors use indoleamine 2,3-dioxygenase-1 (IDO1) as a major mechanism to induce an immunosuppressive microenvironment. IDO1 expression is upregulated in many cancers and considered to be a resistance mechanism to immune...
7.
Kung P, Bingham P, Brooun A, Collins M, Deng Y, Dinh D, et al.
J Med Chem
. 2017 Dec;
61(3):650-665.
PMID: 29211475
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new...
8.
Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, et al.
J Med Chem
. 2017 Nov;
60(23):9617-9629.
PMID: 29111717
Tumors use tryptophan-catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunosuppressive environment. IDO-1 is induced in response to inflammatory stimuli and promotes immune tolerance through effector T-cell anergy...
9.
Kapoor S, Natarajan K, Baldwin P, Doshi K, Lapidus R, Mathias T, et al.
Clin Cancer Res
. 2017 Oct;
24(1):234-247.
PMID: 29074603
-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is present in 30% of acute myeloid leukemia (AML), and these patients have short disease-free survival. FLT3 inhibitors have limited and transient...
10.
Schmidt S, Taeger A, Moriniere J, Liston A, Blank S, Kramp K, et al.
Mol Ecol Resour
. 2016 Oct;
17(4):670-685.
PMID: 27768250
The 'Symphyta' is a paraphyletic assemblage at the base of the order Hymenoptera, comprising 14 families and about 8750 species. All have phytophagous larvae, except for the Orussidae, which are...