Manasvita Vashisth
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Explore the profile of Manasvita Vashisth including associated specialties, affiliations and a list of published articles.
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11
Citations
213
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Recent Articles
1.
Zych M, Contreras M, Vashisth M, Mammel A, Ha G, Hatch E
bioRxiv
. 2024 Sep;
PMID: 39282444
Micronuclei (MN) are a commonly used marker of chromosome instability that form when missegregated chromatin recruits its own nuclear envelope (NE) after mitosis. MN frequently rupture, which results in genome...
2.
Frank S, Persse T, Coleman I, Bankhead 3rd A, Li D, De-Sarkar N, et al.
bioRxiv
. 2024 Jul;
PMID: 39071291
Genomic loss of the transcriptional kinase occurs in ~6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a...
3.
Tobin M, Pfeifer C, Zhu P, Hayes B, Wang M, Vashisth M, et al.
Mol Biol Cell
. 2023 Oct;
34(13):br19.
PMID: 37903225
Chromosome numbers often change dynamically in tumors and cultured cells, which complicates therapy as well as understanding genotype-mechanotype relationships. Here we use a live-cell "ChReporter" method to identify cells with...
4.
Hayes B, Zhu P, Wang M, Pfeifer C, Xia Y, Phan S, et al.
J Cell Sci
. 2023 Jun;
136(11).
PMID: 37288769
The mechanical environment of a cell can have many effects, but whether it impacts the DNA sequence of a cell has remained unexamined. To investigate this, we developed a live-cell...
5.
Dooling L, Andrechak J, Hayes B, Kadu S, Zhang W, Pan R, et al.
Nat Biomed Eng
. 2023 Apr;
7(9):1081-1096.
PMID: 37095318
In solid tumours, the abundance of macrophages is typically associated with a poor prognosis. However, macrophage clusters in tumour-cell nests have been associated with survival in some tumour types. Here,...
6.
Wang M, Ivanovska I, Vashisth M, Discher D
APL Bioeng
. 2022 Jun;
6(2):021504.
PMID: 35719698
Two meters of DNA in each of our cells must be protected against many types of damage. Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of intermediate...
7.
Pfeifer C, Tobin M, Cho S, Vashisth M, Dooling L, Lopez Vazquez L, et al.
Nucleus
. 2022 Mar;
13(1):129-143.
PMID: 35293271
Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear....
8.
Vashisth M, Cho S, Irianto J, Xia Y, Wang M, Hayes B, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(48).
PMID: 34810266
Physicochemical principles such as stoichiometry and fractal assembly can give rise to characteristic scaling between components that potentially include coexpressed transcripts. For key structural factors within the nucleus and extracellular...
9.
Pfeifer C, Vashisth M, Xia Y, Discher D
Essays Biochem
. 2019 Aug;
63(5):569-577.
PMID: 31366473
In many contexts of development, regeneration, or disease such as cancer, a cell squeezes through a dense tissue or a basement membrane, constricting its nucleus. Here, we describe how the...
10.
Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, et al.
Dev Cell
. 2019 May;
49(6):920-935.e5.
PMID: 31105008
Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (∼1 h) to actomyosin stress or ECM elasticity cause rapid and reversible changes...