Manal A Swairjo
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Explore the profile of Manal A Swairjo including associated specialties, affiliations and a list of published articles.
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29
Citations
573
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Recent Articles
1.
de Crecy-Lagard V, Dias R, Friedberg I, Yuan Y, Swairjo M
bioRxiv
. 2024 Jul;
PMID: 39005379
Article Summary: Many proteins in any genome, ranging from 30 to 70%, lack an assigned function. This knowledge gap limits the full use of the vast available genomic data. Machine...
2.
de Crecy-Lagard V, Swairjo M
bioRxiv
. 2024 Jan;
PMID: 38187591
Machine learning-based platforms are currently revolutionizing many fields of molecular biology including structure prediction for monomers or complexes, predicting the consequences of mutations, or predicting the functions of proteins. However,...
3.
Gedara S, Wood E, Gustafson A, Liang C, Hung S, Savage J, et al.
Nucleic Acids Res
. 2023 Mar;
51(8):3836-3854.
PMID: 36928176
The modified nucleosides 2'-deoxy-7-cyano- and 2'-deoxy-7-amido-7-deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the products of the bacterial queuosine tRNA modification pathway and the dpd gene cluster, the...
4.
Hung S, Elliott G, Ramkumar T, Burtnyak L, McGrenaghan C, Alkuzweny S, et al.
Nucleic Acids Res
. 2023 Jan;
51(2):935-951.
PMID: 36610787
Eukaryotic life benefits from-and ofttimes critically relies upon-the de novo biosynthesis and supply of vitamins and micronutrients from bacteria. The micronutrient queuosine (Q), derived from diet and/or the gut microbiome,...
5.
Lee D, Bartels C, McNair K, Edwards R, Swairjo M, Luque A
Comput Struct Biotechnol J
. 2022 Feb;
20:721-732.
PMID: 35140890
Tailed phages are viruses that infect bacteria and are the most abundant biological entities on Earth. Their ecological, evolutionary, and biogeochemical roles in the planet stem from their genomic diversity....
6.
Kot W, Olsen N, Nielsen T, Hutinet G, de Crecy-Lagard V, Cui L, et al.
Nucleic Acids Res
. 2020 Sep;
48(18):10383-10396.
PMID: 32941607
In the constant evolutionary battle against mobile genetic elements (MGEs), bacteria have developed several defense mechanisms, some of which target the incoming, foreign nucleic acids e.g. restriction-modification (R-M) or CRISPR-Cas...
7.
Swinehart W, Deutsch C, Sarachan K, Luthra A, Bacusmo J, de Crecy-Lagard V, et al.
RNA
. 2020 May;
26(9):1094-1103.
PMID: 32385138
-threonylcarbamoyl adenosine (tA) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to...
8.
Samaan G, Paranagama N, Haque A, Hecht D, Swairjo M, Purse B
Bioorg Med Chem Lett
. 2019 Nov;
30(2):126818.
PMID: 31771800
GTP cyclohydrolase (GCYH-I) is an enzyme in the folate biosynthesis pathway that has not been previously exploited as an antibiotic target, although several pathogens including N. gonorrhoeae use a form...
9.
Yuan Y, Zallot R, Grove T, Payan D, Martin-Verstraete I, Sepic S, et al.
Proc Natl Acad Sci U S A
. 2019 Sep;
116(38):19126-19135.
PMID: 31481610
Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and...
10.
Luthra A, Paranagama N, Swinehart W, Bayooz S, Phan P, Quach V, et al.
Nucleic Acids Res
. 2019 May;
47(12):6551-6567.
PMID: 31114923
The universally conserved N6-threonylcarbamoyladenosine (t6A) modification of tRNA is essential for translational fidelity. In bacteria, t6A biosynthesis starts with the TsaC/TsaC2-catalyzed synthesis of the intermediate threonylcarbamoyl adenylate (TC-AMP), followed by...