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Makoto Makishima

Explore the profile of Makoto Makishima including associated specialties, affiliations and a list of published articles. Areas
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Articles 235
Citations 5243
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Recent Articles
1.
Kiaei N, Malik A, Idahosa S, Lee K, Endo-Umeda K, Makishima M, et al.
Biochem Biophys Res Commun . 2025 Feb; 751:151453. PMID: 39923459
Bile acids (BAs) are signaling molecules involved in energy expenditure, glucose homeostasis, and immune system regulation via activation of BA receptors, such as Takeda G-Protein-Coupled Receptor 5 (TGR5), Farnesoid X...
2.
Suzuki Y, Hayashi K, Goto F, Nomura Y, Fujimoto C, Makishima M
Cell Death Discov . 2024 Aug; 10(1):382. PMID: 39191766
Age-related hearing loss (ARHL) is one of the most prevalent types of sensory decline in a superaging society. Although various studies have focused on the effect of oxidative stress on...
3.
Ishizawa M, Takano M, Kittaka A, Matsumoto T, Makishima M
Biomolecules . 2024 Jun; 14(6). PMID: 38927109
The active form of vitamin D, 1α,25-dihydroxyvitamin D [1,25(OH)D], is a principal regulator of calcium homeostasis through activation of the vitamin D receptor (VDR). Previous studies have shown that 2α-(3-hydroxypropyl)-1,25D...
4.
Tanaka Y, Fujihara M, Takamura Y, Kawasaki M, Nakano S, Makishima M, et al.
ACS Med Chem Lett . 2024 May; 15(5):640-645. PMID: 38746897
There is no straightforward method to visualize the intracellular distribution of nuclear receptors, such as retinoid X receptors (RXRs), which are trafficked between the cytosol and nucleus. Here, in order...
5.
Ohni S, Yamaguchi H, Hirotani Y, Nakanishi Y, Midorikawa Y, Sugitani M, et al.
Am J Transl Res . 2024 Mar; 16(2):690-699. PMID: 38463590
To clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic...
6.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, et al.
Sci Rep . 2023 Jul; 13(1):12355. PMID: 37524814
Molecular targeted therapy using poly (ADP-ribose) polymerase inhibitors has improved survival in patients with castration-resistant prostate cancer (CRPC). However, this approach is only effective in patients with specific genetic mutations,...
7.
Maekawa K, Ishizawa M, Ikawa T, Sajiki H, Matsumoto T, Tokiwa H, et al.
Biomolecules . 2023 Jul; 13(7). PMID: 37509118
The active form of vitamin D, 1α,25-dihydroxyvitamin D [1,25(OH)D], is a major regulator of calcium homeostasis through activation of the vitamin D receptor (VDR). We have previously synthesized vitamin D...
8.
Kubota H, Ishizawa M, Kodama M, Nagase Y, Kato S, Makishima M, et al.
Int J Mol Sci . 2023 Feb; 24(4). PMID: 36834927
Bile acids are major components of bile; they emulsify dietary lipids for efficient digestion and absorption and act as signaling molecules that activate nuclear and membrane receptors. The vitamin D...
9.
Li X, Guo L, Sato F, Kitayama T, Tewari N, Makishima M, et al.
J Periodontal Res . 2022 Aug; 57(5):1056-1069. PMID: 35989621
Background And Objectives: The potential role of the transcription factor Differentiated embryo-chondrocyte 2 (Dec2) in the progression of inflammatory diseases such as periodontitis has been unclear. Here, the effect of...
10.
Takada I, Hidano S, Takahashi S, Yanaka K, Ogawa H, Tsuchiya M, et al.
J Biol Chem . 2022 Aug; 298(9):102342. PMID: 35933014
Ess2, also known as Dgcr14, is a transcriptional co-regulator of CD4 T cells. Ess2 is located in a chromosomal region, the loss of which has been associated with 22q11.2 deletion...