Maike Kosanke
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Explore the profile of Maike Kosanke including associated specialties, affiliations and a list of published articles.
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11
Citations
66
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Recent Articles
1.
Dardano M, Kleemiss F, Kosanke M, Lang D, Wilson L, Franke A, et al.
Nat Cell Biol
. 2024 Oct;
26(11):1984-1996.
PMID: 39379702
Despite the biomedical importance of haematopoietic stem cells and haematopoietic progenitor cells, their in vitro stabilization in a developmental context has not been achieved due to limited knowledge of signals...
2.
Wu X, Zheng L, Reboll M, Hyde L, Mass E, Niessen H, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(2):186-202.
PMID: 39196188
Tissue repair after myocardial infarction (MI) is guided by autocrine and paracrine-acting proteins. Deciphering these signals and their upstream triggers is essential when considering infarct healing as a therapeutic target....
3.
Burkart V, Kowalski K, Disch A, Hilfiker-Kleiner D, Lal S, Dos Remedios C, et al.
J Mol Cell Cardiol
. 2023 Oct;
185:26-37.
PMID: 37797718
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease. Up to 40% of cases are associated with heterozygous mutations in myosin binding protein C (cMyBP-C, MYBPC3). Most of these...
4.
Myosin expression and contractile function are altered by replating stem cell-derived cardiomyocytes
Osten F, Weber N, Wendland M, Holler T, Piep B, Krohn S, et al.
J Gen Physiol
. 2023 Sep;
155(11).
PMID: 37656049
Myosin heavy chain (MyHC) is the main determinant of contractile function. Human ventricular cardiomyocytes (CMs) predominantly express the β-isoform. We previously demonstrated that ∼80% of human embryonic stem cell-derived cardiomyocytes...
5.
Amrute-Nayak M, Gand L, Khan B, Holler T, Kefalakes E, Kosanke M, et al.
Cell Rep
. 2022 Nov;
41(8):111702.
PMID: 36417853
Disorganization of the basic contractile unit of muscle cells, i.e., the sarcomeres, leads to suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that the nuclear...
6.
Reboll M, Klede S, Taft M, Cai C, Field L, Lavine K, et al.
Science
. 2022 Jun;
376(6599):1343-1347.
PMID: 35709278
Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a...
7.
Adriawan I, Atschekzei F, Dittrich-Breiholz O, Garantziotis P, Hirsch S, Risser L, et al.
Ann Rheum Dis
. 2021 Sep;
81(1):124-131.
PMID: 34583923
Objectives: Giant cell arteritis (GCA) is the most common primary vasculitis, preferentially affecting the aorta and its large-calibre branches. An imbalance between proinflammatory CD4 T helper cell subsets and regulatory...
8.
Zur Bruegge T, Liese A, Donath S, Kalies S, Kosanke M, Dittrich-Breiholz O, et al.
Stem Cells Int
. 2021 Sep;
2021:9041423.
PMID: 34580592
In recent years, stem cell-derived organoids have become a cell culture standard that is widely used for studying various scientific issues that were previously investigated through animal experiments and using...
9.
Kosanke M, Davenport C, Szepes M, Wiehlmann L, Kohrn T, Dorda M, et al.
Stem Cell Reports
. 2021 Sep;
16(10):2488-2502.
PMID: 34560000
Therapeutic application of induced pluripotent stem cell (iPSC) derivatives requires comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) to exclude oncogenic potential and functional deficits. It...
10.
Reprogramming enriches for somatic cell clones with small-scale mutations in cancer-associated genes
Kosanke M, Osetek K, Haase A, Wiehlmann L, Davenport C, Schwarzer A, et al.
Mol Ther
. 2021 Apr;
29(8):2535-2553.
PMID: 33831558
Cellular therapies based on induced pluripotent stem cells (iPSCs) come out of age and an increasing number of clinical trials applying iPSC-based transplants are ongoing or in preparation. Recent studies,...