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» Authors » Mahesh Thirunavukkarasu

Mahesh Thirunavukkarasu

Explore the profile of Mahesh Thirunavukkarasu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 55
Citations 968
Followers 0
Related Specialties
Cardiology & Vascular Diseases
Biochemistry
Molecular Biology
Top 10 Co-Authors
Nilanjana Maulik
Lijun Zhan
Vaithinathan Selvaraju
Suresh Varma Penumathsa
J Alexander Palesty
Juan A Sanchez
David W McFadden
Samson Mathews Samuel
Hajime Otani
Gautam Maulik
Published In
J Mol Cell Cardiol
Int J Cardiol
Am J Physiol Heart Circ Physiol
Microvasc Res
Surgery
Affiliations
Soon will be listed here.
Recent Articles
1.
COVID-19 Associated Cardiovascular Disease-Risks, Prevention and Management: Heart at Risk Due to COVID-19
Kemerley A, Gupta A, Thirunavukkarasu M, Maloney M, Burgwardt S, Maulik N
Curr Issues Mol Biol . 2024 Mar; 46(3):1904-1920. PMID: 38534740
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the resulting COVID-19 pandemic have had devastating and lasting impact on the global population. Although the main target of the disease...
2.
Novel approaches to determine the functional role of cardiomyocyte specific E3 ligase, Pellino-1 following myocardial infarction
Pradeep S, Thirunavukkarasu M, Accorsi D, Swaminathan S, Lim S, Cernuda B, et al.
Biochim Biophys Acta Mol Basis Dis . 2023 Oct; 1870(1):166899. PMID: 37778482
Objectives: Ubiquitination plays a vital role in controlling vascular inflammation, cellular protein quality control, and minimizing misfolded protein toxicity. Pellino-1 (Peli1), a type of E3 ubiquitin ligase, has emerged as...
3.
Biodegradable piezoelectric skin-wound scaffold
Das R, Le T, Schiff B, Chorsi M, Park J, Lam P, et al.
Biomaterials . 2023 Aug; 301:122270. PMID: 37591188
Electrical stimulation (ES) induces wound healing and skin regeneration. Combining ES with the tissue-engineering approach, which relies on biomaterials to construct a replacement tissue graft, could offer a self-stimulated scaffold...
4.
Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model
Thirunavukkarasu M, Swaminathan S, Kemerley A, Pradeep S, Lim S, Accorsi D, et al.
Cells . 2023 Jun; 12(11). PMID: 37296648
Objectives: Intra-abdominal sepsis is commonly diagnosed in the surgical population and remains the second most common cause of sepsis overall. Sepsis-related mortality remains a significant burden in the intensive care...
5.
Driving adult tissue repair via re-engagement of a pathway required for fetal healing
Ghatak S, Khanna S, Roy S, Thirunavukkarasu M, Pradeep S, Wulff B, et al.
Mol Ther . 2022 Sep; 31(2):454-470. PMID: 36114673
Fetal cutaneous wound closure and repair differ from that in adulthood. In this work, we identify an oxidant stress sensor protein, nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), that is abundantly...
6.
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model
Pradeep S, Lim S, Thirunavukkarasu M, Joshi M, Cernuda B, Palesty J, et al.
J Am Coll Surg . 2022 Jun; 235(2):240-254. PMID: 35758926
Background: Our earlier studies showed that inhibiting prolyl-4-hydroxylase enzymes (PHD-1 and PHD-3) improves angiogenesis, heart function, and limb perfusion in mouse models via stabilizing hypoxia-inducible transcription factor-alpha (HIF-1α). The present...
7.
Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model
Thirunavukkarasu M, Pradeep S, Ukani G, Abunnaja S, Youssef M, Accorsi D, et al.
Microvasc Res . 2022 Jan; 141:104311. PMID: 34999110
Objectives: In the United States, over 8.5 million people suffer from peripheral arterial disease (PAD). Previously we reported that Pellino-1(Peli1) gene therapy reduces ischemic damage in the myocardium and skin...
8.
Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia
Thirunavukkarasu M, Tipu Rishi M, Pradeep S, Swaminathan S, Accorsi D, Palesty J, et al.
Surgery . 2021 Jun; 170(3):969-977. PMID: 34092373
Background: Heat shock protein A12B expressed in endothelial cells is important and required for angiogenesis to form functional vessels in ischemic tissue. We have previously shown the cardioprotective effects of...
9.
Engineered resveratrol-loaded fibrous scaffolds promotes functional cardiac repair and regeneration through Thioredoxin-1 mediated VEGF pathway
Campbell J, Lakshmanan R, Selvaraju V, Accorsi D, McFadden D, Maulik N, et al.
Int J Pharm . 2021 Feb; 597:120236. PMID: 33539996
Despite recent advancements, mortality due to coronary heart disease (CHD) remains high. Recently, the use of tissue-engineered grafts and scaffolds has emerged as a candidate for supporting the myocardium after...
10.
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models
Selvaraju V, Thirunavukkarasu M, Joshi M, Oriowo B, Shaikh I, Tipu Rishi M, et al.
Basic Res Cardiol . 2020 Jun; 115(4):45. PMID: 32537701
Introduction: In the present study, we aimed to explore the functional role of Pellino-1 (Peli1) in inducing neovascularization after myocardial infarction (MI) and hindlimb ischemia (HLI) using Peli1 global knockout...