Magali Waelbroeck
Overview
Explore the profile of Magali Waelbroeck including associated specialties, affiliations and a list of published articles.
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16
Citations
242
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Recent Articles
1.
van der Woning B, De Boeck G, Blanchetot C, Bobkov V, Klarenbeek A, Saunders M, et al.
MAbs
. 2016 May;
8(6):1126-35.
PMID: 27211075
The identification of functional monoclonal antibodies directed against G-protein coupled receptors (GPCRs) is challenging because of the membrane-embedded topology of these molecules. Here, we report the successful combination of llama...
2.
Roberts D, Vertongen P, Waelbroeck M
Peptides
. 2011 Jun;
32(8):1593-9.
PMID: 21704096
Glucagon is an important hormone for the prevention of hypoglycemia, and contributes to the hyperglycemia observed in diabetic patients, yet very little is known about its receptor structure and the...
3.
Waelbroeck M
Biochem Mol Biol Educ
. 2011 May;
35(4):233-7.
PMID: 21591099
Why should we think of enzymes as sluice gates? We are used to talk about "metabolic flux": I should like to suggest that we should indeed envision metabolism as a...
4.
Prevost M, Vertongen P, Raussens V, Roberts D, Cnudde J, Perret J, et al.
J Biol Chem
. 2010 Jul;
285(40):30951-8.
PMID: 20647307
The glucagon receptor belongs to the B family of G-protein coupled receptors. Little structural information is available about this receptor and its association with glucagon. We used the substituted cysteine...
5.
Wuest M, Weiss A, Waelbroeck M, Braeter M, Kelly L, Hakenberg O, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2006 Oct;
374(2):87-97.
PMID: 17053897
Propiverine is a commonly used antimuscarinic drug used as therapy for symptoms of an overactive bladder. Propiverine is extensively biotransformed into several metabolites that could contribute to its spasmolytic action....
6.
Kostenis E, Waelbroeck M, Milligan G
Trends Pharmacol Sci
. 2005 Sep;
26(11):595-602.
PMID: 16183138
Assay technologies that measure the activation of heterotrimeric (alphabetagamma) G proteins by G-protein-coupled receptors (GPCRs) are well established within the pharmaceutical industry, either for pharmacological characterization or for the identification...
7.
Xu L, Depoortere I, Vertongen P, Waelbroeck M, Robberecht P, Peeters T
Biochem Pharmacol
. 2005 Aug;
70(6):879-87.
PMID: 16076462
Unlabelled: The motilin receptor (MTLR) represents a clinically useful pharmacological target, as agonists binding to the MTLR have gastroprokinetic properties. In order to compare the molecular basis for interaction of...
8.
Roberts D, Waelbroeck M
Biochem Pharmacol
. 2004 Aug;
68(5):799-806.
PMID: 15294442
G protein coupled receptors catalyze the GDP/GTP exchange on G proteins, thereby activating them. The ternary complex model, designed to describe agonist binding in the absence of GTP, is often...
9.
De Vriese C, Gregoire F, Lema-Kisoka R, Waelbroeck M, Robberecht P, Delporte C
Endocrinology
. 2004 Jul;
145(11):4997-5005.
PMID: 15256494
The endogenous ligand for the GH secretagogue receptor is ghrelin, a peptide recently purified from the stomach. Ghrelin is n-octanoylated on the Ser(3) residue, and this modification is essential for...
10.
Waelbroeck M
Neurochem Res
. 2003 Apr;
28(3-4):419-22.
PMID: 12675125
The binding properties of muscarinic acetylcholine receptors are affected by various drugs acting at a second (allosteric) binding site, usually (but not always) at supratherapeutic concentrations. Allosteric drugs acting at...