David J Roberts
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Explore the profile of David J Roberts including associated specialties, affiliations and a list of published articles.
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213
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8199
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Recent Articles
1.
Tokolyi A, Persyn E, Nath A, Burnham K, Marten J, Vanderstichele T, et al.
Nat Genet
. 2025 Mar;
57(3):616-625.
PMID: 40038547
The biological mechanisms through which most nonprotein-coding genetic variants affect disease risk are unknown. To investigate gene-regulatory mechanisms, we mapped blood gene expression and splicing quantitative trait loci (QTLs) through...
2.
Hoffmann S, Schrezenmeier E, Desmarets M, Halleck F, Durrbach A, Peters L, et al.
EBioMedicine
. 2025 Feb;
113:105613.
PMID: 40020259
Background: COVID-19 convalescent plasma (CCP) is a treatment option for COVID-19. This study investigated the safety and efficacy of early, very high-titre CCP in immunocompromised individuals with mild COVID-19. Methods:...
3.
Qi H, Wood A, Kaptoge S, McMahon A, Mehenny S, Kingston N, et al.
Transfusion
. 2025 Feb;
PMID: 40001299
Background: In England, blood donors with low hemoglobin concentration are deferred following on-session testing to prevent donations below regulatory thresholds, thereby protecting donors' health and blood supply quality. However, deferrals...
4.
Murphy M, Brailsford S, Roberts D
Blood
. 2025 Feb;
PMID: 39938022
The UK Infected Blood Inquiry report was published in May 2024 after 6 years of taking oral and written evidence from patients, clinicians, blood services, government officials and politicians about...
5.
Nurmi V, Mayne R, Knight C, Almonacid-Mendoza H, Secret S, Estcourt L, et al.
J Infect
. 2025 Jan;
90(2):106412.
PMID: 39798805
Objectives: Convalescent plasma (CP) treatment of COVID-19 has shown significant therapeutic effect only when administered early. We investigated the importance of patient and CP seroprofiles on treatment outcome in REMAP-CAP...
6.
Spensley K, Hassan S, Roberts D, Przybysiak M, Regan F, Brown C, et al.
Am J Transplant
. 2024 Dec;
PMID: 39689811
It is widely accepted that blood transfusions can cause allosensitization, but it is often reported that new human leukocyte antigen (HLA) antibodies are nonspecific and transient. This study explores the...
7.
Rabcuka J, Smethurst P, Dammert K, Saker J, Aran G, Walsh G, et al.
EBioMedicine
. 2024 Dec;
111:105498.
PMID: 39674089
Background: Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. Whereas oxygen-carrying capacity is routinely reported using haemoglobin assays, the rate of...
8.
Allara E, Bell S, Smith R, Keene S, Gill D, Gaziano L, et al.
Commun Biol
. 2024 Dec;
7(1):1631.
PMID: 39643614
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation...
9.
Avgoustou P, Jailani A, Desai A, Roberts D, Lilley E, Stothard G, et al.
Front Pharmacol
. 2024 Oct;
15:1455231.
PMID: 39376604
Introduction: Receptor activity-modifying proteins (RAMPs) are known to modulate the pharmacology and function of several G-protein-coupled receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R). However, the precise effects of...
10.
Willicombe M, Roberts D
Kidney Int
. 2024 Aug;
106(5):795-805.
PMID: 39181398
Human leukocyte antigen (HLA) sensitization remains an impediment to successful solid organ transplantation, whether it be chances of receiving a transplant offer or subsequent transplant longevity. Current treatments targeting HLA...