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Magali Michaut

Explore the profile of Magali Michaut including associated specialties, affiliations and a list of published articles. Areas
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Articles 43
Citations 1247
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Recent Articles
1.
Rehn M, Wenzel A, Frank A, Schuster M, Pundhir S, Jorgensen N, et al.
Cell Rep . 2022 May; 39(6):110793. PMID: 35545054
Ribosomopathies constitute a range of disorders associated with defective protein synthesis mainly affecting hematopoietic stem cells (HSCs) and erythroid development. Here, we demonstrate that deletion of poly-pyrimidine-tract-binding protein 1 (PTBP1)...
2.
Nakamura A, Wong Y, Venturato A, Michaut M, Venkateswaran S, Santra M, et al.
Stem Cell Reports . 2022 Apr; 17(5):1215-1228. PMID: 35452596
With the aim of producing β cells for replacement therapies to treat diabetes, several protocols have been developed to differentiate human pluripotent stem cells to β cells via pancreatic progenitors....
3.
Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, et al.
Mol Cancer Ther . 2022 Jan; 21(4):594-606. PMID: 35086954
Multivalent second-generation TRAIL-R2 agonists are currently in late preclinical development and early clinical trials. Herein, we use a representative second-generation agent, MEDI3039, to address two major clinical challenges facing these...
4.
Mittempergher L, Piskorz A, Bosma A, Michaut M, Wisman G, Kluin R, et al.
PLoS One . 2020 Jul; 15(7):e0235766. PMID: 32639993
High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall survival has been achieved. Identification of recurring "driver" genetic...
5.
Sondergaard E, Rauch A, Michaut M, Rapin N, Rehn M, Wilhelmson A, et al.
Cell Rep . 2019 Nov; 29(9):2756-2769.e6. PMID: 31775043
B cell development depends on the coordinated expression and cooperation of several transcription factors. Here we show that the transcription factor ETS-related gene (ERG) is crucial for normal B cell...
6.
Song Y, Westerhuis J, Aben N, Michaut M, Wessels L, Smilde A
Brief Bioinform . 2019 Jan; 20(1):317-329. PMID: 30657888
Motivation: Genome-wide measurements of genetic and epigenetic alterations are generating more and more high-dimensional binary data. The special mathematical characteristics of binary data make the direct use of the classical...
7.
Sobral-Leite M, Van de Vijver K, Michaut M, van der Linden R, Hooijer G, Horlings H, et al.
Oncoimmunology . 2018 Dec; 7(12):e1509820. PMID: 30524905
To better understand the expression pattern of programmed death-ligand 1 (PD-L1) expression in different breast cancer types, we characterized PD-L1 expression in tumor and tumor-infiltrating immune cells, in relation to...
8.
Aben N, Westerhuis J, Song Y, Kiers H, Michaut M, Smilde A, et al.
Bioinformatics . 2018 Nov; 34(17):i988-i996. PMID: 30423084
Motivation: In biology, we are often faced with multiple datasets recorded on the same set of objects, such as multi-omics and phenotypic data of the same tumors. These datasets are...
9.
Anupama J, Francescatto M, Rahman F, Fatima N, DeBlasio D, Shanmugam A, et al.
PLoS Comput Biol . 2018 Jan; 14(1):e1005802. PMID: 29346365
Education and training are two essential ingredients for a successful career. On one hand, universities provide students a curriculum for specializing in one's field of study, and on the other,...
10.
Kolluri K, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, et al.
Elife . 2018 Jan; 7. PMID: 29345617
Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of...