Madhusudhan Srinivasan
Overview
Explore the profile of Madhusudhan Srinivasan including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
317
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Recent Articles
1.
Cameron G, Gruszka D, Gruar R, Xie S, Kaya C, Nasmyth K, et al.
Science
. 2024 Mar;
384(6691):119-124.
PMID: 38484038
Newly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion coordinates with DNA replication is poorly understood. Prevailing models suggest that cohesin complexes, bound...
2.
Srinivasan M, Fumasoni M, Petela N, Murray A, Nasmyth K
Elife
. 2020 Jun;
9.
PMID: 32515737
Sister chromatid cohesion essential for mitotic chromosome segregation is thought to involve the co-entrapment of sister DNAs within cohesin rings. Although cohesin can load onto chromosomes throughout the cell cycle,...
3.
Srinivasan M, Petela N, Scheinost J, Collier J, Voulgaris M, B Roig M, et al.
Elife
. 2019 Jun;
8.
PMID: 31225797
Cohesin's association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during...
4.
Srinivasan M, Scheinost J, Petela N, Gligoris T, Wissler M, Ogushi S, et al.
Cell
. 2018 May;
173(6):1508-1519.e18.
PMID: 29754816
As predicted by the notion that sister chromatid cohesion is mediated by entrapment of sister DNAs inside cohesin rings, there is perfect correlation between co-entrapment of circular minichromosomes and sister...
5.
Beckouet F, Srinivasan M, Roig M, Chan K, Scheinost J, Batty P, et al.
Mol Cell
. 2016 Feb;
61(4):563-574.
PMID: 26895425
Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin's Scc1, Smc1, and Smc3 subunits is created during S and destroyed at anaphase through...
6.
Sampath V, Liu B, Tafrov S, Srinivasan M, Rieger R, Chen E, et al.
J Biol Chem
. 2013 Jun;
288(30):21506-13.
PMID: 23775086
Based on their sequences, the Saccharomyces cerevisiae Hpa2 and Hpa3 proteins are annotated as two closely related members of the Gcn5 acetyltransferase family. Here, we describe the biochemical characterization of...
7.
Yu Y, Srinivasan M, Nakanishi S, Leatherwood J, Shilatifard A, Sternglanz R
Mol Cell Biol
. 2011 Mar;
31(11):2311-25.
PMID: 21444721
A screen of Saccharomyces cerevisiae histone alanine substitution mutants revealed that mutations in any of three adjacent residues, L97, Y98, or G99, near the C terminus of H4 led to...
8.
Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin E, Karzai A, et al.
EMBO J
. 2010 Dec;
30(5):873-81.
PMID: 21183954
The highly conserved Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/Endopeptidase-like and Kinase associated to transcribed Chromatin (EKC) protein complex has been implicated in transcription, telomere maintenance and chromosome...