Kim A Nasmyth
Overview
Explore the profile of Kim A Nasmyth including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
629
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0
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Recent Articles
1.
Sharma N, Coticchio G, Borini A, Tachibana K, Nasmyth K, Schuh M
Curr Biol
. 2024 Oct;
34(22):5131-5148.e6.
PMID: 39437784
Oocyte loss, a natural process that accelerates as women approach their mid-30s, poses a significant challenge to female reproduction. Recent studies have identified DNA damage as a primary contributor to...
2.
Cameron G, Gruszka D, Gruar R, Xie S, Kaya C, Nasmyth K, et al.
Science
. 2024 Mar;
384(6691):119-124.
PMID: 38484038
Newly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion coordinates with DNA replication is poorly understood. Prevailing models suggest that cohesin complexes, bound...
3.
Nasmyth K, Lee B, Roig M, Lowe J
Elife
. 2023 Nov;
12.
PMID: 37975572
Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During...
4.
Kaushik A, Than T, Petela N, Voulgaris M, Percival C, Daniels P, et al.
Nat Commun
. 2023 Sep;
14(1):5929.
PMID: 37739959
The ring-shaped cohesin complex is a key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated...
5.
Collier J, Nasmyth K
Elife
. 2022 Sep;
11.
PMID: 36094369
The ring model proposes that sister chromatid cohesion is mediated by co-entrapment of sister DNAs inside a single tripartite cohesin ring. The model explains how Scc1 cleavage triggers anaphase but...
6.
Petela N, Gonzalez Llamazares A, Dixon S, Hu B, Lee B, Metson J, et al.
Elife
. 2021 Jul;
10.
PMID: 34259632
Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being 'clamped' by Scc2 and...
7.
Collier J, Lee B, Roig M, Yatskevich S, Petela N, Metson J, et al.
Elife
. 2020 Sep;
9.
PMID: 32930661
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called...
8.
Zhang K, Wu D, Zheng H, Wang Y, Sun Q, Liu X, et al.
Mol Cell
. 2020 Jun;
79(2):234-250.e9.
PMID: 32579944
Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of 3D chromatin structure in this process remains poorly understood. Using low-input Hi-C,...
9.
Srinivasan M, Fumasoni M, Petela N, Murray A, Nasmyth K
Elife
. 2020 Jun;
9.
PMID: 32515737
Sister chromatid cohesion essential for mitotic chromosome segregation is thought to involve the co-entrapment of sister DNAs within cohesin rings. Although cohesin can load onto chromosomes throughout the cell cycle,...
10.
Rhodes J, Feldmann A, Hernandez-Rodriguez B, Diaz N, Brown J, Fursova N, et al.
Cell Rep
. 2020 Jan;
30(3):820-835.e10.
PMID: 31968256
How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene...