Frederic Beckouet
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Explore the profile of Frederic Beckouet including associated specialties, affiliations and a list of published articles.
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17
Citations
958
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Recent Articles
1.
Meneu L, Chapard C, Serizay J, Westbrook A, Routhier E, Ruault M, et al.
Science
. 2025 Feb;
387(6734):eadm9466.
PMID: 39913590
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in...
2.
Normand C, Dez C, Dauban L, Queille S, Danche S, Abderrahmane S, et al.
RNA Biol
. 2024 Jul;
21(1):1-16.
PMID: 39049162
Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome. RNA polymerase...
3.
Bastie N, Chapard C, Cournac A, Nejmi S, Mboumba H, Gadal O, et al.
Mol Cell
. 2024 Mar;
84(6):1139-1148.e5.
PMID: 38452765
Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of chromosomes (SMC) complexes such as cohesin, condensin, and Smc5/6. This organization regulates different DNA-related processes along the cell...
4.
Bastie N, Chapard C, Dauban L, Gadal O, Beckouet F, Koszul R
Nat Struct Mol Biol
. 2022 Jun;
29(6):575-585.
PMID: 35710835
Cohesin is a DNA translocase that is instrumental in the folding of the genome into chromatin loops, with functional consequences on DNA-related processes. Chromatin loop length and organization likely depend...
5.
Dauban L, Montagne R, Thierry A, Lazar-Stefanita L, Bastie N, Gadal O, et al.
Mol Cell
. 2020 Feb;
77(6):1279-1293.e4.
PMID: 32032532
Cohesin, a member of the SMC complex family, holds sister chromatids together but also shapes chromosomes by promoting the formation of long-range intra-chromatid loops, a process proposed to be mediated...
6.
Dauban L, Kamgoue A, Wang R, Leger-Silvestre I, Beckouet F, Cantaloube S, et al.
J Struct Biol
. 2019 Aug;
208(2):152-164.
PMID: 31449968
Spatial organisation of chromosomes is a determinant of genome stability and is required for proper mitotic segregation. However, visualization of individual chromatids in living cells and quantification of their geometry,...
7.
Srinivasan M, Petela N, Scheinost J, Collier J, Voulgaris M, B Roig M, et al.
Elife
. 2019 Jun;
8.
PMID: 31225797
Cohesin's association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during...
8.
Beckouet F, Srinivasan M, Roig M, Chan K, Scheinost J, Batty P, et al.
Mol Cell
. 2016 Feb;
61(4):563-574.
PMID: 26895425
Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin's Scc1, Smc1, and Smc3 subunits is created during S and destroyed at anaphase through...
9.
Gligoris T, Scheinost J, Burmann F, Petela N, Chan K, Uluocak P, et al.
Science
. 2014 Nov;
346(6212):963-7.
PMID: 25414305
Through their association with a kleisin subunit (Scc1), cohesin's Smc1 and Smc3 subunits are thought to form tripartite rings that mediate sister chromatid cohesion. Unlike the structure of Smc1/Smc3 and...
10.
B Roig M, Lowe J, Chan K, Beckouet F, Metson J, Nasmyth K
FEBS Lett
. 2014 Aug;
588(20):3692-702.
PMID: 25171859
Sister chromatid cohesion involves entrapment of sister DNAs by a cohesin ring created through association of a kleisin subunit (Scc1) with ATPase heads of Smc1/Smc3 heterodimers. Cohesin's association with chromatin...