Madhumati Sevvana
Overview
Explore the profile of Madhumati Sevvana including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
923
Followers
0
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Recent Articles
1.
Dowd K, Sirohi D, Speer S, VanBlargan L, Chen R, Mukherjee S, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(3):e2218899120.
PMID: 36638211
Cleavage of the flavivirus premembrane (prM) structural protein during maturation can be inefficient. The contribution of partially mature flavivirus virions that retain uncleaved prM to pathogenesis during primary infection is...
2.
Sevvana M, Keck Z, Foung S, Kuhn R
Curr Opin Virol
. 2021 Jun;
49:92-101.
PMID: 34091143
The molecular mechanisms of hepatitis C virus (HCV) persistence and pathogenesis are poorly understood. The design of an effective HCV vaccine is challenging despite a robust humoral immune response against...
3.
Nicholls C, Sevvana M, Kuhn R
Adv Virus Res
. 2021 Apr;
108:33-83.
PMID: 33837721
The flavivirus genus encompasses more than 75 unique viruses, including dengue virus which accounts for almost 390 million global infections annually. Flavivirus infection can result in a myriad of symptoms...
4.
Sevvana M, Rogers T, Miller A, Long F, Klose T, Beutler N, et al.
Viruses
. 2020 Dec;
12(12).
PMID: 33255202
Zika virus (ZIKV), a mosquito-borne human flavivirus that causes microcephaly and other neurological disorders, has been a recent focus for the development of flavivirus vaccines and therapeutics. We report here...
5.
Sevvana M, Kuhn R
Curr Opin Virol
. 2020 Aug;
45:51-64.
PMID: 32801077
Flaviviruses are emerging arthropod-borne RNA viruses, causing a broad spectrum of life-threatening disease symptoms such as encephalitis and hemorrhagic fever. Successful vaccines exist against yellow fever virus, Japanese encephalitis virus...
6.
Sevvana M, Ruf M, Uson I, Sheldrick G, Herbst-Irmer R
Acta Crystallogr D Struct Biol
. 2019 Dec;
75(Pt 12):1040-1050.
PMID: 31793898
In contrast to twinning by merohedry, the reciprocal lattices of the different domains of non-merohedral twins do not overlap exactly. This leads to three kinds of reflections: reflections with no...
7.
Long F, Doyle M, Fernandez E, Miller A, Klose T, Sevvana M, et al.
Proc Natl Acad Sci U S A
. 2019 Jan;
116(5):1591-1596.
PMID: 30642974
Zika virus (ZIKV) is a major human pathogen and member of the genus in the Flaviviridae family. In contrast to most other insect-transmitted flaviviruses, ZIKV also can be transmitted sexually...
8.
Sevvana M, Long F, Miller A, Klose T, Buda G, Sun L, et al.
Structure
. 2018 Jul;
26(9):1169-1177.e3.
PMID: 29958768
Among the several arthropod-borne human flaviviral diseases, the recent outbreak of Zika virus (ZIKV) has caused devastating birth defects and neurological disorders, challenging the world with another major public health...
9.
Hasan S, Sevvana M, Kuhn R, Rossmann M
Nat Struct Mol Biol
. 2018 Jan;
25(1):13-20.
PMID: 29323278
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV)...
10.
Andreani J, Bou Khalil J, Sevvana M, Benamar S, Di Pinto F, Bitam I, et al.
J Virol
. 2017 Apr;
91(14).
PMID: 28446673
, a double-stranded DNA virus that infects pigs, is the only known member of the family. Nevertheless, during our isolation and sequencing of the complete genome of faustovirus, followed by...