Madeline E Sherlock
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Explore the profile of Madeline E Sherlock including associated specialties, affiliations and a list of published articles.
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24
Citations
961
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Recent Articles
1.
Sherlock M, Langeberg C, Segar K, Kieft J
Cell Rep
. 2025 Feb;
44(2):115236.
PMID: 39893634
Certain viral RNAs encode proteins downstream of their main open reading frame, expressed through "termination-reinitiation" events. In some cases, structures located upstream of the first stop codon within these viral...
2.
Sherlock M, Langeberg C, Kieft J
RNA
. 2024 Jan;
30(3):213-222.
PMID: 38164607
Certain positive-sense single-stranded RNA viruses contain elements at their 3' termini that structurally mimic tRNAs. These tRNA-like structures (TLSs) are classified based on which amino acid is covalently added to...
3.
Sherlock M, Langeberg C, Segar K, Kieft J
bioRxiv
. 2023 Oct;
PMID: 37808774
Certain viral RNAs encode proteins downstream of the main protein coding region, expressed through "termination-reinitiation" events, dependent on RNA structure. RNA elements located upstream of the first stop codon within...
4.
Sherlock M, Galvis L, Vicens Q, Kieft J, Jagannathan S
RNA
. 2023 Apr;
29(7):865-884.
PMID: 37024263
The gene expression pathway from DNA sequence to functional protein is not as straightforward as simple depictions of the central dogma might suggest. Each step is highly regulated, with complex...
5.
Sherlock M, Higgs G, Yu D, Widner D, White N, Sudarsan N, et al.
RNA Biol
. 2022 Sep;
19(1):1059-1076.
PMID: 36093908
Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer domain result in ordinary dose-response curves that require approximately a 100-fold change in ligand concentration...
6.
Bonilla S, Sherlock M, Macfadden A, Kieft J
Science
. 2021 Nov;
374(6570):955-960.
PMID: 34793227
Viruses require multifunctional structured RNAs to hijack their host’s biochemistry, but their mechanisms can be obscured by the difficulty of solving conformationally dynamic RNA structures. Using cryo–electron microscopy (cryo-EM), we...
7.
Langeberg C, Sherlock M, Macfadden A, Kieft J
RNA
. 2021 Apr;
27(6):653-664.
PMID: 33811147
Structured RNA elements are common in the genomes of RNA viruses, often playing critical roles during viral infection. Some viral RNA elements use forms of tRNA mimicry, but the diverse...
8.
Sherlock M, Hartwick E, Macfadden A, Kieft J
RNA
. 2020 Oct;
27(1):27-39.
PMID: 33008837
Viruses commonly use specifically folded RNA elements that interact with both host and viral proteins to perform functions important for diverse viral processes. Examples are found at the 3' termini...
9.
Sherlock M, Breaker R
RNA
. 2020 Mar;
26(6):675-693.
PMID: 32165489
Comparative sequence analyses have been used to discover numerous classes of structured noncoding RNAs, some of which are riboswitches that specifically recognize small-molecule or elemental ion ligands and influence expression...
10.
Sherlock M, Sadeeshkumar H, Breaker R
Biochemistry
. 2018 Aug;
58(5):401-410.
PMID: 30081631
The ykkC RNA motif was a long-standing orphan riboswitch candidate that has recently been proposed to encompass at least five distinct bacterial riboswitch classes. Most ykkC RNAs belong to the...