Andrea Macfadden
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Explore the profile of Andrea Macfadden including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
181
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Recent Articles
1.
Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate
Nichols P, Krall J, Henen M, Welty R, Macfadden A, Vicens Q, et al.
J Am Chem Soc
. 2023 Dec;
146(1):677-694.
PMID: 38131335
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA when bound by Zα domains found within a variety of innate immune response proteins. Zα domains...
2.
Maurina S, OSullivan J, Sharma G, Rodriguez D, Macfadden A, Cendali F, et al.
J Mol Biol
. 2023 Sep;
435(20):168259.
PMID: 37660941
An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Non-structural protein 1 (Nsp1), which suppresses host gene expression and stunts antiviral signaling. SARS-CoV-2 Nsp1 binds the ribosome to inhibit...
3.
Maurina S, OSullivan J, Sharma G, Rodriguez D, Macfadden A, Cendali F, et al.
bioRxiv
. 2023 Jun;
PMID: 37333070
An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Nsp1, which suppresses host gene expression and stunts antiviral signaling. SARS-CoV-2 Nsp1 binds the ribosome to inhibit translation through mRNA...
4.
White L, Strugar S, Macfadden A, Hesselberth J
RNA
. 2023 Feb;
29(6):847-861.
PMID: 36854608
Ligation by plant and fungal RNA ligases yields an internal 2'-phosphate group on each RNA ligation product. In budding yeast, this covalent mark occurs at the splice junction of two...
5.
Bonilla S, Sherlock M, Macfadden A, Kieft J
Science
. 2021 Nov;
374(6570):955-960.
PMID: 34793227
Viruses require multifunctional structured RNAs to hijack their host’s biochemistry, but their mechanisms can be obscured by the difficulty of solving conformationally dynamic RNA structures. Using cryo–electron microscopy (cryo-EM), we...
6.
Langeberg C, Sherlock M, Macfadden A, Kieft J
RNA
. 2021 Apr;
27(6):653-664.
PMID: 33811147
Structured RNA elements are common in the genomes of RNA viruses, often playing critical roles during viral infection. Some viral RNA elements use forms of tRNA mimicry, but the diverse...
7.
Sherlock M, Hartwick E, Macfadden A, Kieft J
RNA
. 2020 Oct;
27(1):27-39.
PMID: 33008837
Viruses commonly use specifically folded RNA elements that interact with both host and viral proteins to perform functions important for diverse viral processes. Examples are found at the 3' termini...
8.
Hartwick E, Costantino D, Macfadden A, Nix J, Tian S, Das R, et al.
Nat Commun
. 2018 Dec;
9(1):5074.
PMID: 30498211
Structured RNA elements, programmed RNA conformational changes, and interactions between different RNA domains underlie many modes of regulating gene expression, mandating studies to understand the foundational principles that govern these...
9.
Macfadden A, ODonoghue Z, Silva P, Chapman E, Olsthoorn R, Sterken M, et al.
Nat Commun
. 2018 Jan;
9(1):119.
PMID: 29317714
Flaviviruses such as Yellow fever, Dengue, West Nile, and Zika generate disease-linked viral noncoding RNAs called subgenomic flavivirus RNAs. Subgenomic flavivirus RNAs result when the 5'-3' progression of cellular exoribonuclease...
10.
Jacobson A, Macfadden A, Wu Z, Peng J, Liu C
Mol Biol Cell
. 2014 Apr;
25(12):1824-35.
PMID: 24743594
The 26S proteasome degrades ubiquitinated proteins, and proteasomal degradation controls various cellular events. Here we report that the human 26S proteasome is ubiquitinated, by which the ubiquitin receptors Adrm1 and...