Philip C Bevilacqua
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Explore the profile of Philip C Bevilacqua including associated specialties, affiliations and a list of published articles.
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178
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4959
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Recent Articles
1.
Saon M, Douds C, Veenis A, Pearson A, Yennawar N, Bevilacqua P
bioRxiv
. 2025 Jan;
PMID: 39803426
RNA can serve as an enzyme, small molecule sensor, and vaccine, and it may have been a conduit for the origin of life. Despite these profound functions, RNA is thought...
2.
McKinley L, Bevilacqua P
Methods
. 2024 Dec;
234:120-130.
PMID: 39662711
Small self-cleaving ribozymes are catalytic RNAs that cleave their phosphodiester backbone rapidly and site-specifically, without the assistance of proteins. Their catalytic properties make them ideal targets for applications in RNA...
3.
McKinley L, Meyer M, Sebastian A, Chang B, Messina K, Albert I, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):14133-14153.
PMID: 39498486
Twister ribozymes are an extensively studied class of nucleolytic RNAs. Thousands of natural twisters have been proposed using sequence homology and structural descriptors. Yet, most of these candidates have not...
4.
McKinley L, Meyer M, Sebastian A, Chang B, Messina K, Albert I, et al.
bioRxiv
. 2024 Jul;
PMID: 39026743
Graphical Abstract:
5.
Douds C, Babitzke P, Bevilacqua P
RNA
. 2024 Apr;
30(7):901-919.
PMID: 38670632
A key to understanding the roles of RNA in regulating gene expression is knowing their structures in vivo. One way to obtain this information is through probing the structures of...
6.
7.
McKinley L, Kern R, Assmann S, Bevilacqua P
Biochemistry
. 2023 Dec;
63(1):53-68.
PMID: 38134329
Small nucleolytic ribozymes are RNAs that cleave their own phosphodiester backbone. While proteinaceous enzymes are regulated by a variety of known mechanisms, methods of regulation for ribozymes remain unclear. Twister...
8.
Meyer M, Choi S, Keating C, Bevilacqua P, Yamagami R
Methods Enzymol
. 2023 Nov;
691:81-126.
PMID: 37914453
There is a multitude of small (<100nt) RNAs that serve diverse functional roles in biology. Key amongst these is transfer RNA (tRNA), which is among the most ancient RNAs and...
9.
Sieg J, Jolley E, Huot M, Babitzke P, Bevilacqua P
Nucleic Acids Res
. 2023 Oct;
51(20):11298-11317.
PMID: 37855684
We conducted a thermodynamic analysis of RNA stability in Eco80 artificial cytoplasm, which mimics in vivo conditions, and compared it to transcriptome-wide probing of mRNA. Eco80 contains 80% of Escherichia...
10.
Meyer M, Yamagami R, Choi S, Keating C, Bevilacqua P
Sci Adv
. 2023 Sep;
9(38):eadh5152.
PMID: 37729412
Compartmentalization of RNA in biopolymer-rich membraneless organelles is now understood to be pervasive and critical for the function of extant biology and has been proposed as a prebiotically plausible way...