Madeline E Kavanagh
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Explore the profile of Madeline E Kavanagh including associated specialties, affiliations and a list of published articles.
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19
Citations
192
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Recent Articles
1.
Kavanagh M, McLean K, Gilbert S, Amadi C, Snee M, Tunnicliffe R, et al.
bioRxiv
. 2025 Jan;
PMID: 39803573
() is the world's most deadly infectious pathogen and new drugs are urgently required to combat the emergence of multi- (MDR) and extensively- (XDR) drug resistant strains. The bacterium specifically...
2.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
3.
Katariya M, Snee M, Tunnicliffe R, Kavanagh M, Boshoff H, Amadi C, et al.
Chemistry
. 2023 Mar;
29(29):e202203868.
PMID: 36912255
Mycobacterium tuberculosis (Mtb) was responsible for approximately 1.6 million deaths in 2021. With the emergence of extensive drug resistance, novel therapeutic agents are urgently needed, and continued drug discovery efforts...
4.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798186
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
5.
Kavanagh M, Horning B, Khattri R, Roy N, Lu J, Whitby L, et al.
Nat Chem Biol
. 2022 Sep;
18(11):1288.
PMID: 36180594
No abstract available.
6.
Kavanagh M, Horning B, Khattri R, Roy N, Lu J, Whitby L, et al.
Nat Chem Biol
. 2022 Sep;
18(12):1388-1398.
PMID: 36097295
The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. JAK...
7.
Frederickson M, Selvam I, Evangelopoulos D, McLean K, Katariya M, Tunnicliffe R, et al.
Eur J Med Chem
. 2022 Jan;
230:114105.
PMID: 35065413
There is a pressing need for new drugs against tuberculosis (TB) to combat the growing resistance to current antituberculars. Herein a novel strategy is described for hit generation against promising...
8.
Brem J, Panduwawala T, Ulf Hansen J, Hewitt J, Liepins E, Donets P, et al.
Nat Chem
. 2021 Dec;
14(1):15-24.
PMID: 34903857
Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1...
9.
Abbasov M, Kavanagh M, Ichu T, Lazear M, Tao Y, Crowley V, et al.
Nat Chem
. 2021 Sep;
13(11):1151.
PMID: 34588639
No abstract available.
10.
Abbasov M, Kavanagh M, Ichu T, Lazear M, Tao Y, Crowley V, et al.
Nat Chem
. 2021 Sep;
13(11):1081-1092.
PMID: 34504315
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic electrophiles have been evaluated...