Maarten Van Roy
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Explore the profile of Maarten Van Roy including associated specialties, affiliations and a list of published articles.
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10
Citations
280
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Recent Articles
1.
Fontaine T, Busch A, Laeremans T, De Cesco S, Liang Y, Jaakola V, et al.
Nat Commun
. 2024 Oct;
15(1):7029.
PMID: 39353917
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety....
2.
Desmyter A, Spinelli S, Boutton C, Saunders M, Blachetot C, de Haard H, et al.
Front Immunol
. 2017 Sep;
8:884.
PMID: 28871249
The heterodimeric cytokine interleukin (IL) 23 comprises the IL12-shared p40 subunit and an IL23-specific subunit, p19. Together with IL12 and IL27, IL23 sits at the apex of the regulatory mechanisms...
3.
Warnders F, van Scheltinga A, Knuehl C, Van Roy M, de Vries E, Kosterink J, et al.
J Nucl Med
. 2017 Apr;
58(8):1210-1215.
PMID: 28360206
The human epidermal growth factor receptor 3 (HER3) is an interesting target for antitumor therapy. For optimal HER3 signaling inhibition, a biparatopic Nanobody construct (MSB0010853) was developed that binds 2...
4.
Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, et al.
Arthritis Res Ther
. 2015 May;
17:135.
PMID: 25994180
Introduction: The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and...
5.
Maussang D, Mujic-Delic A, Descamps F, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, et al.
J Biol Chem
. 2013 Aug;
288(41):29562-72.
PMID: 23979133
The chemokine receptor CXCR7, belonging to the membrane-bound G protein-coupled receptor superfamily, is expressed in several tumor types. Inhibition of CXCR7 with either small molecules or small interference (si)RNA has...
6.
Van Hauwermeiren F, Armaka M, Karagianni N, Kranidioti K, Vandenbroucke R, Loges S, et al.
J Clin Invest
. 2013 May;
123(6):2590-603.
PMID: 23676465
TNF has remarkable antitumor activities; however, therapeutic applications have not been possible because of the systemic and lethal proinflammatory effects induced by TNF. Both the antitumor and inflammatory effects of...
7.
Momi S, Tantucci M, Van Roy M, Ulrichts H, Ricci G, Gresele P
Blood
. 2013 Apr;
121(25):5088-97.
PMID: 23589671
Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding....
8.
Van Roy M, Van Lint P, Van Laere I, Wielockx B, Wilson C, Lopez-Otin C, et al.
Mol Cancer Ther
. 2007 Sep;
6(9):2563-71.
PMID: 17876053
The potent antitumor activity of tumor necrosis factor (TNF) in combination with IFN-gamma can only be applied in local regimens due to their strong proinflammatory properties. It has been shown...
9.
Van Molle W, Van Roy M, Van Bogaert T, Dejager L, Van Lint P, Vanlaere I, et al.
Cancer Res
. 2007 Aug;
67(15):7301-7.
PMID: 17671199
Tumor necrosis factor (TNF)-induced inflammation prevents its broad application as an antitumor agent. We here report that addition of ZnSO(4) to the drinking water of mice induces expression of heat...
10.
Wielockx B, Staelens J, Puimege L, Vanlaere I, Van Roy M, Van Lint P, et al.
J Immunol
. 2007 Apr;
178(8):5069-75.
PMID: 17404289
In our search for genes that inhibit the inflammatory effects of TNF without diminishing its antitumor capacities we found that, compared with C57BL/6 mice, DBA/2 mice exhibit a dominant resistance...