Jan Staelens
Overview
Explore the profile of Jan Staelens including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
174
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Recent Articles
1.
Puimege L, Van Hauwermeiren F, Steeland S, Van Ryckeghem S, Vandewalle J, Lodens S, et al.
EMBO Mol Med
. 2015 May;
7(8):1004-17.
PMID: 25995337
TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced...
2.
Van Hauwermeiren F, Armaka M, Karagianni N, Kranidioti K, Vandenbroucke R, Loges S, et al.
J Clin Invest
. 2013 May;
123(6):2590-603.
PMID: 23676465
TNF has remarkable antitumor activities; however, therapeutic applications have not been possible because of the systemic and lethal proinflammatory effects induced by TNF. Both the antitumor and inflammatory effects of...
3.
Staelens J, Rombaut D, Vercauteren I, Argue B, Benzie J, Vuylsteke M
Genetics
. 2008 Jun;
179(2):917-25.
PMID: 18558652
We report on the construction of sex-specific high-density linkage maps and identification of sex-linked markers for the black tiger shrimp (Penaeus monodon). Overall, we identified 44 male and 43 female...
4.
Wielockx B, Staelens J, Puimege L, Vanlaere I, Van Roy M, Van Lint P, et al.
J Immunol
. 2007 Apr;
178(8):5069-75.
PMID: 17404289
In our search for genes that inhibit the inflammatory effects of TNF without diminishing its antitumor capacities we found that, compared with C57BL/6 mice, DBA/2 mice exhibit a dominant resistance...
5.
Mahieu T, Park J, Revets H, Pasche B, Lengeling A, Staelens J, et al.
Proc Natl Acad Sci U S A
. 2006 Feb;
103(7):2292-7.
PMID: 16455798
Although activation of Toll-like receptor 4 (TLR4)-positive cells is essential for eliminating Gram-negative bacteria, overactivation of these cells by the TLR4 ligand LPS initiates a systemic inflammatory reaction and shock....
6.
Staelens J, Puimege L, Mahieu T, Pynaert G, Hochepied T, Vandenabeele A, et al.
Mamm Genome
. 2004 Sep;
15(7):537-43.
PMID: 15366373
Most inflammatory disorders are becoming more prevalent, especially in Western countries. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) plays a prominent role in many of these inflammatory disorders. We have...
7.
Hochepied T, Schoonjans L, Staelens J, Kreemers V, Danloy S, Puimege L, et al.
Stem Cells
. 2004 Jul;
22(4):441-7.
PMID: 15277691
Embryonic stem (ES) cells, which can differentiate into almost all types of cells, have been derived from the house mouse Mus musculus, rat, rabbit, humans, and other species. Transmission of...
8.
Staelens J, Wielockx B, Puimege L, van Roy F, Guenet J, Libert C
Proc Natl Acad Sci U S A
. 2002 Jun;
99(14):9340-5.
PMID: 12089334
Tumor necrosis factor (TNF) is a central mediator in lethal shock and an interesting cytokine for anticancer therapy. To inhibit TNF-induced lethal shock, it is important to identify protective genes....