Maarten van Dinther
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Explore the profile of Maarten van Dinther including associated specialties, affiliations and a list of published articles.
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41
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1361
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Recent Articles
1.
White S, Schwartze T, Mukundan A, Schoenherr C, Singh S, van Dinther M, et al.
Nat Commun
. 2025 Feb;
16(1):1847.
PMID: 39984487
TGM6 is a natural antagonist of mammalian TGF-β signaling produced by the murine helminth parasite Heligmosomoides polygyrus. It differs from the previously described agonist, TGM1 (TGF-β Mimic-1), in that it...
2.
Singh S, Smyth D, Cunningham K, Mukundan A, Byeon C, Hinck C, et al.
EMBO Rep
. 2024 Nov;
26(1):218-244.
PMID: 39609640
The immunoregulatory cytokine TGF-β is pleiotropic due to the near-ubiquitous expression of the TGF-β receptors TβRI and TβRII on diverse cell types. The helminth parasite Heligmosomoides polygyrus has convergently evolved...
3.
White S, Schwartze T, Mukundan A, Schoenherr C, Singh S, van Dinther M, et al.
bioRxiv
. 2024 Jan;
PMID: 38187573
The murine helminth parasite expresses a family of proteins structurally related to TGF-β Mimic 1 (TGM1), a secreted five domain protein that activates the TGF-β pathway and converts naïve T...
4.
Singh S, Smyth D, Cunningham K, Mukundan A, Byeon C, Hinck C, et al.
bioRxiv
. 2023 Nov;
PMID: 38014296
The murine helminth parasite expresses a family of modular proteins which, replicating the functional activity of the immunomodulatory cytokine TGF-β, have been named TGM (TGF-β Μimic). Multiple domains bind to...
5.
van Dinther M, Cunningham K, Singh S, White M, Campion T, Ciancia C, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2302370120.
PMID: 37590410
Long-lived parasites evade host immunity through highly evolved molecular strategies. The murine intestinal helminth, , down-modulates the host immune system through release of an immunosuppressive TGF-β mimic, TGM1, which is...
6.
Liu S, van Dinther M, Hagenaars S, Gu Y, Kuipers T, Mei H, et al.
Int J Cancer
. 2023 Feb;
152(12):2594-2606.
PMID: 36823950
Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to its aggressive characteristics and low response to the existing clinical therapies. Distant metastasis is the...
7.
Zhang J, van Dinther M, Thorikay M, Mousavi Gourabi B, Kruithof B, Ten Dijke P
Cell Mol Life Sci
. 2023 Jan;
80(2):43.
PMID: 36646950
Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates the stability and function of multiple proteins, thereby controlling various biological responses. The alternative splicing of USP19 results in the expression...
8.
Iyengar P, Marvin D, Lama D, Tan T, Suriyamurthy S, Xie F, et al.
Mol Cancer Res
. 2022 Jun;
20(10):1516-1531.
PMID: 35731212
Implications: Our findings identify E3 ubiquitin ligase TRAF4 as a potential therapeutic target or biomarker for bladder cancer progression.
9.
Marvin D, You L, Bornes L, van Dinther M, Peters N, Dang H, et al.
Cancers (Basel)
. 2022 May;
14(10).
PMID: 35626109
Transforming growth factor-β (TGF-β) signaling is tightly controlled in duration and intensity during embryonic development and in the adult to maintain tissue homeostasis. To visualize the TGF-β/SMAD3 signaling kinetics, we...
10.
Sinha A, Mehta P, Fan C, Zhang J, Marvin D, van Dinther M, et al.
Methods Mol Biol
. 2022 Mar;
2488:47-65.
PMID: 35347682
Epithelial to mesenchymal transition (EMT) is crucial during embryonic development, tissue fibrosis, and cancer progression. Epithelial cells that display a cobblestone-like morphology can undergo a switch to mesenchymal-like phenotype, displaying...