M Todd Valerius
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Explore the profile of M Todd Valerius including associated specialties, affiliations and a list of published articles.
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45
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4905
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Recent Articles
11.
Homan K, Gupta N, Kroll K, Kolesky D, Skylar-Scott M, Miyoshi T, et al.
Nat Methods
. 2019 Feb;
16(3):255-262.
PMID: 30742039
Kidney organoids derived from human pluripotent stem cells have glomerular- and tubular-like compartments that are largely avascular and immature in static culture. Here we report an in vitro method for...
12.
Gupta N, Susa K, Yoda Y, Bonventre J, Valerius M, Morizane R
Curr Protoc Stem Cell Biol
. 2018 Jul;
45(1):e50.
PMID: 30040245
Human pluripotent stem cells (hPSCs) represent a formidable tool for disease modeling, drug discovery, and regenerative medicine using human cells and tissues in vitro. Evolving techniques of targeted genome editing,...
13.
Ramalingam H, Fessler A, Das A, Valerius M, Basta J, Robbins L, et al.
Dev Biol
. 2018 Apr;
440(1):13-21.
PMID: 29705331
Formation of a functional kidney depends on the balance between renewal and differentiation of nephron progenitors. Failure to sustain this balance can lead to kidney failure or stem cell tumors....
14.
Naiman N, Fujioka K, Fujino M, Valerius M, Potter S, McMahon A, et al.
Dev Cell
. 2017 May;
41(4):349-365.e3.
PMID: 28535371
The kidney contains the functional units, the nephrons, surrounded by the renal interstitium. Previously we discovered that, once Six2-expressing nephron progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at...
15.
Togel F, Valerius M, Freedman B, Iatrino R, Grinstein M, Bonventre J
JCI Insight
. 2017 Feb;
2(2):e88848.
PMID: 28138555
The neonatal mouse kidney retains nephron progenitor cells in a nephrogenic zone for 3 days after birth. We evaluated whether de novo nephrogenesis can be induced postnatally beyond 3 days....
16.
Oxburgh L, Carroll T, Cleaver O, Gossett D, Hoshizaki D, Hubbell J, et al.
J Am Soc Nephrol
. 2017 Jan;
28(5):1370-1378.
PMID: 28096308
(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and...
17.
18.
Masuzaki R, Zhao S, Valerius M, Tsugawa D, Oya Y, Ray K, et al.
J Biol Chem
. 2015 Dec;
291(7):3346-58.
PMID: 26703468
After significant injury, the liver must maintain homeostasis during the regenerative process. We hypothesized the existence of mechanisms to limit hepatocyte proliferation after injury to maintain metabolic and synthetic function....
19.
Freedman B, Brooks C, Lam A, Fu H, Morizane R, Agrawal V, et al.
Nat Commun
. 2015 Oct;
6:8715.
PMID: 26493500
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney...
20.
Morizane R, Lam A, Freedman B, Kishi S, Valerius M, Bonventre J
Nat Biotechnol
. 2015 Oct;
33(11):1193-200.
PMID: 26458176
Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable organ regeneration, disease modeling and drug screening. We report an efficient, chemically defined protocol for differentiating hPSCs...