Benjamin S Freedman
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Explore the profile of Benjamin S Freedman including associated specialties, affiliations and a list of published articles.
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57
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2178
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Recent Articles
1.
Gulieva R, Ahmadvand P, Freedman B
Stem Cell Reports
. 2025 Jan;
20(2):102395.
PMID: 39855202
The mammalian target of rapamycin (mTOR) pathway is a therapeutic target in polycystic kidney disease (PKD), but mTOR inhibitors such as everolimus have failed to show efficacy at tolerated doses...
2.
Grahammer F, Dumoulin B, Gulieva R, Wu H, Xu Y, Sulaimanov N, et al.
Kidney Int
. 2024 Sep;
106(5):856-869.
PMID: 39218392
Progression of cystic kidney disease has been linked to activation of the mTORC1 signaling pathway. Yet the utility of mTORC1 inhibitors to treat patients with polycystic kidney disease remains controversial...
3.
Pamies D, Ekert J, Zurich M, Frey O, Werner S, Piergiovanni M, et al.
Stem Cell Reports
. 2024 Jul;
PMID: 38959889
No abstract available.
4.
Edman N, Phal A, Redler R, Schlichthaerle T, Srivatsan S, Ehnes D, et al.
Cell
. 2024 Jun;
187(14):3726-3740.e43.
PMID: 38861993
Many growth factors and cytokines signal by binding to the extracellular domains of their receptors and driving association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling...
5.
Juliar B, Stanaway I, Sano F, Fu H, Smith K, Akilesh S, et al.
Cell Rep
. 2024 Jun;
43(6):114310.
PMID: 38838223
Elevated interferon (IFN) signaling is associated with kidney diseases including COVID-19, HIV, and apolipoprotein-L1 (APOL1) nephropathy, but whether IFNs directly contribute to nephrotoxicity remains unclear. Using human kidney organoids, primary...
6.
Pamies D, Ekert J, Zurich M, Frey O, Werner S, Piergiovanni M, et al.
Stem Cell Reports
. 2024 Apr;
19(5):604-617.
PMID: 38670111
Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological...
7.
Vishy C, Thomas C, Vincent T, Crawford D, Goddeeris M, Freedman B
Cell Stem Cell
. 2024 Apr;
31(4):537-553.e5.
PMID: 38579684
In polycystic kidney disease (PKD), microscopic tubules expand into macroscopic cysts. Among the world's most common genetic disorders, PKD is inherited via heterozygous loss-of-function mutations but is theorized to require...
8.
Alghadeer A, Hanson-Drury S, Patni A, Ehnes D, Zhao Y, Li Z, et al.
Dev Cell
. 2023 Aug;
58(20):2163-2180.e9.
PMID: 37582367
Tooth enamel secreted by ameloblasts (AMs) is the hardest material in the human body, acting as a shield to protect the teeth. However, the enamel is gradually damaged or partially...
9.
Freedman B, Dekel B
Curr Transplant Rep
. 2023 May;
10(2):29-39.
PMID: 37128257
Purpose Of Review: Kidney organoids are heterocellular structures grown in vitro that resemble nephrons. Organoids contain diverse cell types, including podocytes, proximal tubules, and distal tubules in contiguous segments, patterned...
10.
Li S, Gulieva R, Helms L, Cruz N, Vincent T, Fu H, et al.
Nat Commun
. 2022 Dec;
13(1):7918.
PMID: 36564419
In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically specific way, but the mechanisms...