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M Pfaff

Explore the profile of M Pfaff including associated specialties, affiliations and a list of published articles. Areas
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Articles 39
Citations 1135
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Recent Articles
11.
Liu S, Thomas S, Woodside D, Rose D, Kiosses W, Pfaff M, et al.
Nature . 1999 Dec; 402(6762):676-81. PMID: 10604475
The alpha4 integrins are indispensable for embryogenesis, haematopoiesis and immune responses, possibly because alpha4 regulates cellular functions differently from other integrins through its cytoplasmic tail. We used novel mimics of...
12.
Pfaff M, Du X, Ginsberg M
FEBS Lett . 1999 Nov; 460(1):17-22. PMID: 10571053
We showed previously that the calcium-dependent protease, calpain, cleaves the cytoplasmic domain of the integrin beta3 subunit. To investigate whether susceptibility to calpain is a common feature of all integrin...
13.
Hughes P, Pfaff M
Trends Cell Biol . 1998 Sep; 8(9):359-64. PMID: 9728397
Integrin cell-adhesion receptors mediate interactions between cells and the extracellular matrix. Dynamic regulation of integrin adhesive function is termed 'activation' or 'inside-out' signalling. Activation is key to integrin function in...
14.
Boissy P, Machuca I, Pfaff M, Ficheux D, Jurdic P
J Cell Sci . 1998 Aug; 111 ( Pt 17):2563-74. PMID: 9701555
Alphavbeta3 is a key integrin mediating adhesion of multinucleated osteoclasts during bone resorption. 1, 25-dihydroxyvitamin D3 upregulates alphavbeta3 integrin expression in mononucleated osteoclast precursors and concomitantly stimulates their differentiation into...
15.
Powers C, Shellock F, Pfaff M
J Magn Reson Imaging . 1998 Jun; 8(3):724-32. PMID: 9626893
The purpose of this study was to describe a method to quantify dynamic patellar tracking using kinematic MRI (KMRI). Twelve normal females and three patients with patellofemoral pain participated. Imaging...
16.
Pfaff M, Liu S, Erle D, Ginsberg M
J Biol Chem . 1998 Apr; 273(11):6104-9. PMID: 9497328
Integrin cytoplasmic domains connect these receptors to the cytoskeleton. Furthermore, integrin-cytoskeletal interactions involve ligand binding (occupancy) to the integrin extracellular domain and clustering of the integrin. To construct mimics of...
17.
Baker E, Tozer E, Pfaff M, Shattil S, Loftus J, Ginsberg M
Proc Natl Acad Sci U S A . 1997 Mar; 94(5):1973-8. PMID: 9050889
Glanzmann thrombasthenia, an inherited bleeding disorder, can be caused by a defect or deficiency in platelet integrin alphaIIb beta3 (GPIIb-IIIa). Studies of thrombasthenia variants have facilitated identification of sites involved...
18.
Hughes P, Renshaw M, Pfaff M, Forsyth J, Keivens V, Schwartz M, et al.
Cell . 1997 Feb; 88(4):521-30. PMID: 9038343
Rapid modulation of ligand binding affinity ("activation") is a central property of the integrin cell adhesion receptors. Using a screen for suppressors of integrin activation, we identified the small GTP-binding...
19.
Pfaff M, Reinhardt D, Sakai L, Timpl R
FEBS Lett . 1996 Apr; 384(3):247-50. PMID: 8617364
Fibrillin-1 is a major constituent of tissue microfibrils that occur in most connective tissues, either in close association with or independent of elastin. To test possible cell-adhesive functions of this...
20.
Wennerberg K, Lohikangas L, Gullberg D, Pfaff M, Johansson S, Fassler R
J Cell Biol . 1996 Jan; 132(1-2):227-38. PMID: 8567726
The mouse cell line GD25, which lacks expression of the beta 1 family of integrin heterodimers due to disruption of the beta 1 integrin subunit gene, was used for expression...