M P Hacker
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Explore the profile of M P Hacker including associated specialties, affiliations and a list of published articles.
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72
Citations
457
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Recent Articles
11.
Hart B, Gong Q, Eneman J, Kimberly P, Hacker M
Toxicology
. 1996 Mar;
107(3):163-75.
PMID: 8604477
This study investigated potential mechanisms of oxidant resistance in alveolar macrophages (AM) isolated from Lewis rats exposed repeatedly to cadmium aerosols. Macrophages from Cd-adapted animals significantly greater resistance to oxidant-induced...
12.
Bhushan A, Wroblewski D, Xuan Y, Tritton T, Hacker M
Biochem Pharmacol
. 1996 Feb;
51(4):477-82.
PMID: 8619893
Collateral resistance to cisplatin and methotrexate has been reported in several cell lines. A murine leukemia cell line (L1210/DDP) selected for cisplatin resistance also has been shown to be highly...
13.
Wroblewski D, Bhushan A, Xuan Y, Brinton B, Tritton T, Hacker M
Cancer Chemother Pharmacol
. 1996 Jan;
37(4):337-42.
PMID: 8548879
We report a murine leukemia cell variant (L1210/DDP), selected for cisplatin (DDP) resistance, to be cross-resistant to methotrexate (MTX). Cross-resistance of L1210 cells to DDP and MTX has been observed...
14.
Hazlehurst L, Krapcho A, Hacker M
Biochem Pharmacol
. 1995 Sep;
50(7):1087-94.
PMID: 7575665
Aza-anthracenediones are a new class of anti-cancer drugs, which demonstrate promising in vitro and in vivo activity. Our laboratory has synthesized a variety of structural analogs in which we determined...
15.
Hazlehurst L, Krapcho A, Hacker M
Cancer Lett
. 1995 May;
91(1):115-24.
PMID: 7750086
Doxorubicin and mitoxantrone are carboxyclic anti-cancer drugs that interact with DNA through intercalation. Our laboratory has synthesized a new series of anti-tumor agents, the aza-anthracenediones, which are structurally related to...
16.
Krapcho A, Maresch M, Hacker M, Menta E, Oliva A, Giuliani F, et al.
Acta Biochim Pol
. 1995 Jan;
42(4):427-32.
PMID: 8852333
Synthetic routes to aza and diaza bioisosteres related to the anthracene-9,10-dione, mitoxantrone, have been developed. The antitumor properties of these chemotypes are compared with those exhibited by the corresponding carbocyclic...
17.
Engelke K, Hacker M
Biochem Biophys Res Commun
. 1994 Aug;
203(1):400-7.
PMID: 8074684
Isoprenylated proteins are believed to play an important role in DNA synthesis and subsequent cell cycle progression. Inhibition of the biosynthesis of these isoprenylated proteins results in a decrease in...
18.
Krapcho A, Petry M, Getahun Z, Landi Jr J, Stallman J, Polsenberg J, et al.
J Med Chem
. 1994 Mar;
37(6):828-37.
PMID: 8145234
Synthetic procedures have been developed which lead to the 2-aza congeners 3 and several related N-oxides 4. The analogues 3 exhibited a wide range of in vitro cytotoxicity against L1210...
19.
Roberts J, Bigelow J, Moore A, Belinson J, Stewart J, Hacker M
J Immunother Emphasis Tumor Immunol
. 1994 Jan;
15(1):53-8.
PMID: 8110731
Circulating neopterin is derived from monocytes and/or macrophages that produce it upon stimulation by interferon-gamma released from activated T cells. Neopterin production has been proposed as a marker of biological...
20.
Zwelling L, Mayes J, Altschuler E, Satitpunwaycha P, Tritton T, Hacker M
Biochem Pharmacol
. 1993 Jul;
46(2):265-71.
PMID: 8394077
We have examined the activities of two novel aza-anthracene-9,10-diones (aza), 1-aza and 2-aza, in HL-60 human leukemia cell lines containing type II topoisomerases with different sensitivities to inhibition by other...