M Nabholz
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Explore the profile of M Nabholz including associated specialties, affiliations and a list of published articles.
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89
Citations
1615
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Recent Articles
1.
Ducrest A, Amacker M, Mathieu Y, Cuthbert A, Trott D, Newbold R, et al.
Cancer Res
. 2001 Oct;
61(20):7594-602.
PMID: 11606399
Telomerase is required for the complete replication of chromosomal ends. In tumors, the human telomerase reverse transcriptase subunit (hTERT) is up-regulated, thereby removing a critical barrier for unlimited cell proliferation....
2.
Szutorisz H, Palmqvist R, Roos G, Stenling R, Schorderet D, Reddel R, et al.
Oncogene
. 2001 Jun;
20(20):2600-5.
PMID: 11420670
Telomerase activation is crucial in human carcinogenesis. The limiting component of telomerase, the catalytic subunit (hTERT), is undetectable in normal somatic cells but present in most tumor cells, including the...
3.
Ehret G, Reichenbach P, Schindler U, Horvath C, Fritz S, Nabholz M, et al.
J Biol Chem
. 2000 Oct;
276(9):6675-88.
PMID: 11053426
STAT transcription factors are expressed in many cell types and bind to similar sequences. However, different STAT gene knock-outs show very distinct phenotypes. To determine whether differences between the binding...
4.
Migliaccio M, Amacker M, Just T, Reichenbach P, Valmori D, Cerottini J, et al.
J Immunol
. 2000 Oct;
165(9):4978-84.
PMID: 11046025
Like most somatic human cells, T lymphocytes have a limited replicative life span. This phenomenon, called senescence, presents a serious barrier to clinical applications that require large numbers of Ag-specific...
5.
Gasser S, Corthesy P, Beerman F, MacDonald H, Nabholz M
J Immunol
. 2000 May;
164(11):5659-67.
PMID: 10820241
We have prepared transgenic mice whose T cells constitutively express a chimeric receptor combining extracellular human IL-4R and intracellular IL-2Rbeta segments. This receptor can transmit IL-2/IL-15-like signals in response to...
6.
Rusterholz C, Henrioud P, Nabholz M
Mol Cell Biol
. 1999 Mar;
19(4):2681-9.
PMID: 10082534
Interleukin-2 (IL-2) responsiveness of T lymphocytes is controlled through transcription of the IL-2 receptor (IL-2R) alpha subunit by antigen and by IL-2 itself. IL-2 induces IL-2Ralpha transcription via an IL-2-responsive...
7.
Meyer W, Reichenbach P, Schindler U, Soldaini E, Nabholz M
J Biol Chem
. 1998 Feb;
272(50):31821-8.
PMID: 9395528
Stimulation of the interleukin 2 receptor alpha (IL-2Ralpha) gene by IL-2 is important for the proliferation of antigen-activated T lymphocytes. IL-2 regulates IL-2Ralpha transcription via a conserved 51-nucleotide IL-2 responsive...
8.
Bucher P, Corthesy P, Imbert J, Nabholz M
Immunobiology
. 1998 Jan;
198(1-3):136-43.
PMID: 9442385
IL-2 stimulates expression of the alpha subunit of the high affinity IL-2 receptor (IL-2R alpha) in antigen-activated T lymphocytes, by increasing IL-2R alpha gene transcription. This response is mediated by...
9.
Serdobova I, Pla M, Reichenbach P, Sperisen P, Ghysdael J, Wilson A, et al.
J Exp Med
. 1997 Apr;
185(7):1211-21.
PMID: 9104808
Lymphocytes regulate their responsiveness to IL-2 through the transcriptional control of the IL-2R alpha gene, which encodes a component of the high affinity IL-2 receptor. In the mouse IL-2R alpha...
10.
Lecine P, Algarte M, Rameil P, Beadling C, Bucher P, Nabholz M, et al.
Mol Cell Biol
. 1997 Apr;
17(4):2351.
PMID: 9121484
No abstract available.