M M Rosenkilde
Overview
Explore the profile of M M Rosenkilde including associated specialties, affiliations and a list of published articles.
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33
Citations
1114
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Recent Articles
11.
Rummel P, Arfelt K, Baumann L, Jenkins T, Thiele S, Luttichau H, et al.
Br J Pharmacol
. 2012 Jun;
167(6):1206-17.
PMID: 22708643
Background And Purpose: Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists,...
12.
Jensen P, Thiele S, Steen A, Elder A, Kolbeck R, Ghosh S, et al.
Br J Pharmacol
. 2011 Nov;
166(1):258-75.
PMID: 22050085
Background And Purpose: The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe...
13.
Lyngaa R, Norregaard K, Kristensen M, Kubale V, Rosenkilde M, Kledal T
Oncogene
. 2010 Jun;
29(31):4388-98.
PMID: 20543866
Epstein-Barr virus (EBV) open reading frame BILF1 encodes a seven trans-membrane (TM) G protein-coupled receptor that signals with high constitutive activity through Galpha(i) (Beisser et al., 2005; Paulsen et al.,...
14.
Benned-Jensen T, Rosenkilde M
Br J Pharmacol
. 2010 Feb;
159(5):1092-105.
PMID: 20148890
Background And Purpose: In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform...
15.
Steen A, Schwartz T, Rosenkilde M
Mini Rev Med Chem
. 2010 Jan;
9(14):1605-21.
PMID: 20088780
CXCR4 and CCR5 constitute the two major coreceptors for HIV-1 entry into host cells. In the course of an HIV-infection, a coreceptor switch takes place in approximately half of the...
16.
Benned-Jensen T, Rosenkilde M
Curr Mol Pharmacol
. 2009 Dec;
2(2):140-8.
PMID: 20021454
During the two past decades tremendous effort has been put into uncovering the activation mechanism of 7TM receptors. The majority of such studies have focused on the major binding pocket,...
17.
Rosenkilde M, Smit M, Waldhoer M
Br J Pharmacol
. 2008 Jan;
153 Suppl 1:S154-66.
PMID: 18204488
A number of human and animal herpes viruses encode G-protein coupled receptors with seven transmembrane (7TM) segments-most of which are clearly related to human chemokine receptors. It appears, that these...
18.
Holst P, Rosenkilde M, Manfra D, Chen S, Wiekowski M, Holst B, et al.
J Clin Invest
. 2001 Dec;
108(12):1789-96.
PMID: 11748262
ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this...
19.
Rosenkilde M, Waldhoer M, Luttichau H, Schwartz T
Oncogene
. 2001 Apr;
20(13):1582-93.
PMID: 11313905
A number of herpes- and poxviruses encode 7TM G-protein coupled receptors most of which clearly are derived from their host chemokine system as well as induce high expression of certain...
20.
Rosenkilde M, Kledal T, Holst P, Schwartz T
J Biol Chem
. 2000 Jun;
275(34):26309-15.
PMID: 10842179
Open reading frame 74 (ORF74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7TM) receptor stimulated by angiogenic chemokines, e.g. growth-related oncogene-alpha, and inhibited by angiostatic...