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M G von Herrath

Explore the profile of M G von Herrath including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 47
Citations 1197
Followers 0
Related Specialties
Allergy & Immunology
General Medicine
Microbiology
Top 10 Co-Authors
M B Oldstone
T Wolfe
B COON
D Homann
J L Whitton
T Dyrberg
J E Gairin
J Dockter
A Bot
H Lewicki
Published In
Clin Exp Immunol
J Immunol
J Exp Med
Immunity
Virology
Affiliations
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Recent Articles
11.
The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes
Bregenholt S, Wang M, Wolfe T, Hughes A, Baerentzen L, Dyrberg T, et al.
Scand J Immunol . 2003 May; 57(5):432-8. PMID: 12753499
When conjugated to various proteins, the nontoxic B-chain of cholera toxin (CTB) significantly increases the ability of these proteins to induce immunological tolerance after oral administration. Here, we investigated if...
12.
Infection-triggered regulatory mechanisms override the role of STAT 4 in control of the immune response to influenza virus antigens
Bot A, Rodrigo E, Wolfe T, Bot S, von Herrath M
J Virol . 2003 Apr; 77(10):5794-800. PMID: 12719572
Accurate control of the balance of the T1 and T2 cells during antiviral immunity is essential for optimizing immune effector functions and for avoiding potentially severe immunopathology. We examined the...
13.
Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus
von Herrath M
Curr Top Microbiol Immunol . 2002 May; 263:145-75. PMID: 11987813
No abstract available.
14.
Protection from type 1 diabetes in the face of high levels of activated autoaggressive lymphocytes in a viral transgenic mouse model crossed to the SV129 strain
von Herrath M, Wolfe T, Mohrle U, COON B, Hughes A
Diabetes . 2001 Nov; 50(12):2700-8. PMID: 11723052
In comparing the incidence of virally induced type 1 diabetes in F(1) crosses of RIP-LCMV mice to three different mouse strains identical at the major histocompatibility complex H-2D(b) locus, we...
15.
Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity
von Herrath M, OLDSTONE M, Homann D, Christen U
Curr Dir Autoimmun . 2001 Sep; 4:91-122. PMID: 11569412
No abstract available.
16.
Design of immune-based interventions in autoimmunity and viral infections--the need for predictive models that integrate time, dose and classes of immune responses
von Herrath M
Novartis Found Symp . 2001 Sep; 239:16-24; discussion 24-30, 45-51. PMID: 11529309
The outcome of both autoimmune reactions and antiviral responses depends on a complex network of multiple components of the immune system. For example, most immune reactions can be viewed as...
17.
A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis
Christen U, Wolfe T, Mohrle U, Hughes A, Rodrigo E, Green E, et al.
J Immunol . 2001 Jun; 166(12):7023-32. PMID: 11390446
We report here that islet-specific expression of TNF-alpha can play a dual role in autoimmune diabetes, depending on its precise timing in relation to the ongoing autoimmune process. In a...
18.
Tolerance induction with agonist peptides recognized by autoaggressive lymphocytes is transient: therapeutic potential for type 1 diabetes is limited and depends on time-point of administration, choice of epitope and adjuvant
von Herrath M, COON B, Wolfe T
J Autoimmun . 2001 May; 16(3):193-9. PMID: 11334483
Immunization with agonist peptides recognized by autoaggressive lymphocytes has been used successfully in several animal models for type 1 diabetes (T1D) or multiple sclerosis (MS) to prevent disease. Depending on...
19.
Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens. Possible role in CD8+ T cell-mediated, virus-induced autoimmune disease
Hudrisier D, Riond J, Burlet-Schiltz O, von Herrath M, Lewicki H, Monsarrat B, et al.
J Biol Chem . 2001 Mar; 276(22):19396-403. PMID: 11278441
Structural similarity (molecular mimicry) between viral epitopes and self-peptides can lead to the induction of autoaggressive CD4(+) as well as CD8(+) T cell responses. Based on the flexibility of T...
20.
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes
Seewaldt S, Thomas H, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, et al.
Diabetes . 2000 Nov; 49(11):1801-9. PMID: 11078446
Autoimmune diabetes is caused by selective loss of insulin-producing pancreatic beta-cells. The main factors directly implicated in beta-cell death are autoreactive, cytotoxic (islet-antigen specific) T-lymphocytes (CTL), and inflammatory cytokines. In...