J L Whitton
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Explore the profile of J L Whitton including associated specialties, affiliations and a list of published articles.
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102
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2922
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Recent Articles
1.
Crocker S, Bajpai R, Moore C, Frausto R, Brown G, Pagarigan R, et al.
Neuropathol Appl Neurobiol
. 2011 Feb;
37(6):643-53.
PMID: 21276029
Aims: Previous studies have demonstrated the therapeutic potential for human embryonic stem cell-derived neural precursor cells (hES-NPCs) in autoimmune and genetic animal models of demyelinating diseases. Herein, we tested whether...
2.
von Herrath M, Whitton J
Curr Protoc Immunol
. 2008 Apr;
Chapter 19:Unit 19.10.
PMID: 18432751
This unit includes protocols for inducing systemic infection and persistent infection of mice with lymphocytic choriomeningitis virus (LCMV). Methods used to measure T cell responses to LCMV are then described....
3.
Feuer R, Whitton J
Curr Top Microbiol Immunol
. 2008 Mar;
323:149-73.
PMID: 18357769
Coxsackieviruses cause substantial human morbidity and mortality, but the underlying molecular mechanisms of disease remain obscure. Here, we review the effects that the cell status--both cellular activation, and the cell...
4.
Leifert J, Holler P, Harkins S, Kranz D, Whitton J
Gene Ther
. 2003 Nov;
10(25):2067-73.
PMID: 14595379
The potential of genetic immunization has been acknowledged for almost a decade, but disappointing immunogenicity in humans has delayed its introduction into the clinical arena. To try to increase the...
5.
Leifert J, Harkins S, Whitton J
Gene Ther
. 2002 Oct;
9(21):1422-8.
PMID: 12378404
Several proteins have been accorded the unusual ability to translocate across cell membranes in a receptor-independent and temperature-independent manner, and this activity has been mapped to a highly basic series...
6.
7.
Leifert J, Lindencrona J, Charo J, Whitton J
Hum Gene Ther
. 2001 Oct;
12(15):1881-92.
PMID: 11589830
Protein transduction domains (PTD), which can transport proteins or peptides across biological membranes, have been identified in several proteins of viral, invertebrate, and vertebrate origin. Here, we evaluate the immunological...
8.
Rodriguez F, Harkins S, Redwine J, de Pereda J, Whitton J
J Virol
. 2001 Oct;
75(21):10421-30.
PMID: 11581410
Our previous studies have shown that targeting DNA vaccine-encoded major histocompatibility complex class I epitopes to the proteasome enhanced CD8(+) T-cell induction and protection against lymphocytic choriomeningitis virus (LCMV) challenge....
9.
Theil D, Tsunoda I, Rodriguez F, Whitton J, Fujinami R
J Neurovirol
. 2001 Aug;
7(3):220-7.
PMID: 11517396
Although many viruses have been isolated from patients with multiple sclerosis (MS), as yet, no one agent has been demonstrated to cause MS. In contrast, epidemiological data indicate that viral...
10.
Slifka M, Whitton J
Nat Immunol
. 2001 Jul;
2(8):711-7.
PMID: 11477407
Unlike B cells, T cells lack the capacity to improve the affinity of their antigen receptors by somatic mutation. It is, therefore, believed that optimization of cellular immunity is mediated...