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M C Fournie-Zaluski

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Articles 178
Citations 2071
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Recent Articles
11.
Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski M, David C, Roques B, et al.
Biochem Soc Trans . 2000 Aug; 28(4):435-40. PMID: 10961935
Overactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several experimental animal models. We have recently reported that, in the murine...
12.
Arbin V, Claperon N, Fournie-Zaluski M, Roques B, Peyroux J
Br J Pharmacol . 2000 Jul; 130(6):1297-304. PMID: 10903969
1. The successive effects of the angiotensin-converting enzyme inhibitor captopril (CAP, 2 mg kg(-1)+1 mg kg(-1) 30 min(-1) infusion) and the neutral endopeptidase 24-11 inhibitor retrothiorphan (RT, 25 mg kg(-1)+12.5...
13.
Marie-Claire C, Tiraboschi G, Ruffet E, Inguimbert N, Fournie-Zaluski M, Roques B
Proteins . 2000 May; 39(4):365-71. PMID: 10813818
Based on the recently described three-dimensional model of the 507-749 region of neprilysin, which contains the catalytic site of the enzyme, experiments were performed to improve the proposed topology of...
14.
Noble F, Luciani N, Da Nascimento S, Lai-Kuen R, Bischoff L, Chen H, et al.
FEBS Lett . 2000 Feb; 467(1):81-6. PMID: 10664461
Aminopeptidase N (APN) is a zinc metallopeptidase involved in the inactivation of biologically active peptides. The knowledge of its precise distribution is crucial to investigate its physiological role. This requires...
15.
David C, Bischoff L, Meudal H, Mothe A, De Mota N, DaNascimento S, et al.
J Med Chem . 1999 Dec; 42(25):5197-211. PMID: 10602705
The study of the physiological roles of the membrane-bound zinc-aminopeptidase A (glutamyl aminopeptidase, EC 3.4.11.7) needs the design of efficient and selective inhibitors of this enzyme. An acute exploration of...
16.
Reaux A, Fournie-Zaluski M, David C, Zini S, Roques B, Corvol P, et al.
Proc Natl Acad Sci U S A . 1999 Nov; 96(23):13415-20. PMID: 10557335
Overactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several experimental models, such as spontaneously hypertensive rats and transgenic mice expressing...
17.
Gaucher J, Selkti M, Tiraboschi G, Prange T, Roques B, Tomas A, et al.
Biochemistry . 1999 Oct; 38(39):12569-76. PMID: 10504225
Three alpha-mercaptoacyldipeptides differing essentially in the size of their C-terminal residues have been crystallized in the thermolysin active site. A new mode of binding was observed for 3 [HS-CH(CH(2)Ph)CO-Phe-Tyr] and...
18.
Ramboarina S, Morellet N, Fournie-Zaluski M, Roques B, Moreller N
Biochemistry . 1999 Jul; 38(30):9600-7. PMID: 10423237
The nucleocapsid proteins (NCps) of lentiviruses play a key role during the retroviral replication cycle. NCps contain one or two highly conserved domains characterized by a CX(2)CX(4)HX(4)C sequence which binds...
19.
Le Guen S, Honore P, Catheline G, Fournie-Zaluski M, Roques B, Besson J
Brain Res . 1999 Jul; 834(1-2):200-6. PMID: 10407116
We have demonstrated that pre-administered RB101 (40 mg/kg, i.v.), a mixed inhibitor of enkephalin-catabolizing enzymes, decreased spinal c-Fos expression induced 1 h and 30 min after intraplantar (i.pl.) carrageenin (41%...
20.
Chen H, Roques B, Fournie-Zaluski M
Bioorg Med Chem Lett . 1999 Jul; 9(11):1511-6. PMID: 10386926
A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in...